Cells in various benign and malignant conditions of the human prostate express different antigenic phenotypes

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dc.authorscopusid6701700119
dc.authorscopusid35570759500
dc.authorscopusid7801581225
dc.authorscopusid35618108000
dc.contributor.authorTurhan O.I.
dc.contributor.authorAydin N.E.
dc.contributor.authorSariyüce O.
dc.contributor.authorÖzkan S.
dc.date.accessioned2024-08-04T19:59:22Z
dc.date.available2024-08-04T19:59:22Z
dc.date.issued1998
dc.departmentİnönü Üniversitesien_US
dc.description.abstractProstatic epithelium basically consists of secretory-luminal, basal and endocrine-paracrine cells. Immunohistochemical procedures are frequently used for showing the cells reflecting different differentiations. In this study, 40 prostatic tissue specimens submitted to the Department of Pathology of Inonu University, Research Hospital, between 1991 and 1996 were examined. Half of the cases were diagnosed as cancer and the other half had various benign lesions. Of the cases 22.5% (n = 9) were needle biopsy material whereas the remainder, 47.5% (n = 19), were from prostatectomy and 30% (n = 12) were transurethral resection of the prostate (TURP) specimens. High molecular weight anti-cytokeratin antibodies (HMW anti-cytokeratin) stained basal cells both in all normal prostatic tissue and benign prostatic lesions, but in the majority of cancers (70%, n = 14) negative immunoreactivity was seen. Nevertheless, in some of the cancer cases (30%, n = 6) basal cell anti- cytokeratin staining was shown. Negative immunoreactivity with HMW anti- cytokeratin is important in distinguishing between malignant and benign lesions, whereas positive staining is not every time in favour of benign lesions. With the usage of prostate specific antigen (PSA) it was seen that all of the malignant and benign prostatic lesions stained positively. Basal cells in hyperplastic glands were not stained with this stain. Irregular, and in some areas, intense (PSA) immunoreactivity is present in precancerous and malignant lesions. Endocrine cells, which are represented with Chromogranin- A (Chr-A) immunoreactivity and reflecting neuroendocrine differentiation, are present in 75% (n = 15) of benign lesions and in 50% (n = 10) of cancer cases. It was thought that the lesser number of these cells in neoplastic lesions in comparison to the non-tumoral lesions is correlated with the disorder of mechanism that regulates the cell growth. Both in neoplastic and nontumoral tissues the prostatic epithelial cells showed the three markers, namely HMW anti-cytokeratin, PSA, and Chr-A, which may reflect the multidirectional differentiation of these cells from a pluripotent origin.en_US
dc.identifier.doi10.1007/BF02564862
dc.identifier.endpage744en_US
dc.identifier.issn0301-1623
dc.identifier.issue6en_US
dc.identifier.pmid10195869en_US
dc.identifier.scopus2-s2.0-0032460573en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage731en_US
dc.identifier.urihttps://doi.org/10.1007/BF02564862
dc.identifier.urihttps://hdl.handle.net/11616/90576
dc.identifier.volume30en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAkademiai Kiado Rt.en_US
dc.relation.ispartofInternational Urology and Nephrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectchromogranin Aen_US
dc.subjectprostate specific antigenen_US
dc.subjectantigen expressionen_US
dc.subjectarticleen_US
dc.subjectbenign tumoren_US
dc.subjectcell differentiationen_US
dc.subjectclinical articleen_US
dc.subjecthumanen_US
dc.subjecthuman tissueen_US
dc.subjectimmunohistochemistryen_US
dc.subjectmaleen_US
dc.subjectmalignant neoplastic diseaseen_US
dc.subjectprostate canceren_US
dc.subjectprostate diseaseen_US
dc.subjectprostatectomyen_US
dc.subjecttransurethral resectionen_US
dc.titleCells in various benign and malignant conditions of the human prostate express different antigenic phenotypesen_US
dc.typeArticleen_US

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