Effects of long-term solvent exposure on blood cytokine levels and antioxidant enzyme activities in house painters

Basit Öğe Kaydı
dc.authoridBatcioglu, Kadir/0000-0001-6663-2287;
dc.authorwosidBatcioglu, Kadir/Q-2424-2015
dc.authorwosid/ABG-9766-2020
dc.contributor.authorKaragözler, AA
dc.contributor.authorMehmet, N
dc.contributor.authorBatçioglu, K
dc.date.accessioned2024-08-04T20:13:11Z
dc.date.available2024-08-04T20:13:11Z
dc.date.issued2002
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of this study was to examine solvent-associated effects on blood cytokine levels, antioxidant enzyme activities, and malondialdehyde (MDA) concentration in house painters. Trace element (Cu and Zn) and nitrite and nitrate levels as well as protein concentrations in erythrocytes and serum were determined. Thirty male house painters and 30 male clerical workers were included in the study. There were 13 smokers and 17 nonsmokers in each group. Hemoglobin concentrations were significantly lower in house-painter blood compared to controls. House painters had significantly higher concentrations of erythrocyte protein (excluding hemoglobin), whereas no significant difference was observed between serum protein levels. Proinflammatory cytokine levels, such as tumor necrosis factor-alpha and interleukin-8, were significantly increased in house painters' sera. Interleukin-6 was below the detection limit of the assay in both groups. Interleukin-1beta and cytokine receptor interleukin 2R concentrations were not significantly affected. Furthermore, a three- to fourfold increase in nitrite and nitrate concentrations was found in house painters' sera. Serum superoxide dismutase (SOD) and glutathione peroxidase (GSHPx) activities were significantly lower in house painters compared to controls. Malondialdehyde (MDA) concentration, a measure of lipid peroxidation, was found to be significantly elevated. In house painters, erythrocyte carbonic anhydrase and catalase activities were elevated approximately 11- fold and 2-fold, respectively. Zinc levels were significantly decreased in house painters' sera. Smoking was not found to be a major confounder for the association between solvent exposure and blood parameters.en_US
dc.identifier.doi10.1080/00984100290071306
dc.identifier.endpage1246en_US
dc.identifier.issn1528-7394
dc.identifier.issn1087-2620
dc.identifier.issue17en_US
dc.identifier.pmid12167207en_US
dc.identifier.scopus2-s2.0-0037072673en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1237en_US
dc.identifier.urihttps://doi.org/10.1080/00984100290071306
dc.identifier.urihttps://hdl.handle.net/11616/93461
dc.identifier.volume65en_US
dc.identifier.wosWOS:000177683300002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofJournal of Toxicology and Environmental Health-Part A-Current Issuesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSerum Bile-Acidsen_US
dc.subjectGlycol Monoethyl Etheren_US
dc.subjectOrganic-Solventsen_US
dc.subjectNitric-Oxideen_US
dc.subjectOccupational Exposureen_US
dc.subjectSuperoxide-Dismutaseen_US
dc.subjectBiological-Fluidsen_US
dc.subjectSpray Paintersen_US
dc.subjectWorkersen_US
dc.subjectCanceren_US
dc.titleEffects of long-term solvent exposure on blood cytokine levels and antioxidant enzyme activities in house paintersen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu