Ülseratif kolitli hastalarda C-reaktif protein/albumin oranının endoskopik ve mukozal aktivite ile ilişkisi
Küçük Resim Yok
Tarih
2022
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
İnönü Üniversitesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Bu çalışmada, ülseratif kolitli hastalarda C-reaktif protein/albumin oranının endoskopik ve mukozal aktivite ile ilişkisinin retrospektif olarak değerlendirilmesi amaçlanmıştır. Gereç ve Yöntem: Araştırmada İnönü Üniversitesi Tıp Fakültesi Gastroenteroloji Bilim Dalı Gastroenteroloji ve İnflamatuar Bağırsak Hastalıkları polikliniklerine 2019-2021 yılları arasında başvurmuş, 18 yaş üstü, patolojik olarak ülseratif kolit tanısı almış, laboratuvar tetkiklerinde ve hasta dosyalarında yeterli veri elde edilen, 74 hasta incelenmiştir. Çalışmada hastaların yaş, cinsiyet gibi demografik özellikleri, Rachmilewitz endoskopik aktivite indeksi, histopatolojik aktivitesi tespit edilmiştir. Hastaların laboratuar sonuçlarında CRP, albumin, hemoglobin, lökosit, nötrofil, monosit, lenfosit, trombosit ve sedimentasyon değerleri incelenmiştir. Bulgular ve Sonuç: Hastalar histolojik aktivite açısından değerlendirildiğinde aktif koliti olanların CRP (p<0,001), CRP/albumin (p<0,001), lökosit (p=0,004), nötrofil (p=0,003), monosit (p=0,009), trombosit (p<0,001) ve sedimantasyon (p=0,001) değerlerinin histolojik olarak aktif koliti olmayanların değerlerinden anlamlı şekilde yüksek, albumin (p<0,001) ve hemoglobin (p=0,031) değerlerinin ise anlamlı şekilde düşük olduğu görülmüştür. Endoskopik olarak aktif olanların (EAI?4) CRP (p<0,001), CRP/albumin (p<0,001), lökosit (p=0,001), nötrofil (p=0,001), monosit (p=0,024), trombosit (p=0,002) ve sedimantasyon (p=0,001) değerleri endoskopik olarak remisyonda olanların (EAI<4) değerlerinden anlamlı şekilde yüksek ve albumin (p=0,001) değeri ise anlamlı şekilde düşük olduğu görülmüştür. Endoskopik aktivite ve histolojik aktivite ile CRP/albumin oranı arasında pozitif yönde anlamlı bir korelasyon olduğu görülmüştür (p<0,001). Aktif kolit varlığı durumuna göre CRP/albumin değeri üzerinden yapılan ROC analizine göre kesme noktası 0,08 olarak bulunmuştur. Bu kesme noktadaki duyarlılık %75, özgüllük ise %96,67 olarak bulunmuştur. Pozitif prediktif değer %97,06 olarak, negatif prediktif değer ise %72,46 olarak bulunmuştur. Anahtar Kelimeler: Ülseratif kolit, CRP/Albumin oranı, endoskopik aktivite
Introduction: In this study, it was aimed to retrospectively evaluate the relationship between C-reactive protein/albumin ratio and endoscopic and mucosal activity in patients with ulcerative colitis. Material and Methods: In the study, 74 patients over the age of 18, who applied to the Gastroenterology and Inflammatory Bowel Diseases polyclinics of Inonu University Faculty of Medicine Gastroenterology Department between 2019-2021, who were diagnosed with ulcerative colitis pathologically, and who had sufficient data in laboratory tests and patient files, were examined. In the study, demographic characteristics such as age and gender, Rachmilewitz endoscopic activity index, and histopathological activity were determined. In the laboratory results of the patients, CRP, albumin, hemoglobin, leukocytes, neutrophils, monocytes, lymphocytes, thrombocyte and sedimentation values were examined. Results and Conclusion: When the patients were evaluated in terms of histological activity, those with active colitis had CRP (p<0,001), CRP/albumin (p<0,001), leukocytes (p=0,004), neutrophils (p=0,003), monocytes (p=0,009), thrombocyte (p<0,001) and sedimentation (p=0.001) values were found to be significantly higher than those without histologically active colitis, while albumin (p<0,001) and hemoglobin (p=0,031) values were found to be significantly lower. Those with endoscopically active colitis (EAI?4) CRP (p<0,001), CRP/albumin (p<0,001), leukocytes (p=0,001), neutrophils (p=0,001), monocytes (p=0,024), platelets (p=0,002) and sedimentation (p=0,001) values were found to be significantly higher than those in remission endoscopically (EAI<4), and albumin (p=0,001) values were found to be significantly lower. It was observed that there was a positive and significant correlation between endoscopic activity and histological activity and the CRP/albumin ratio. The cut-off point was found to be 0,08 according to the ROC analysis performed on the CRP/albumin value according to the presence of active colitis. The sensitivity at this cut-off point was 75%, and the specificity was 96,67%. The positive predictive value was 97,06%, and the negative predictive value was 72,46%. Keywords: Ulcerative colitis, CRP/Albumin ratio, endoscopic activity
Introduction: In this study, it was aimed to retrospectively evaluate the relationship between C-reactive protein/albumin ratio and endoscopic and mucosal activity in patients with ulcerative colitis. Material and Methods: In the study, 74 patients over the age of 18, who applied to the Gastroenterology and Inflammatory Bowel Diseases polyclinics of Inonu University Faculty of Medicine Gastroenterology Department between 2019-2021, who were diagnosed with ulcerative colitis pathologically, and who had sufficient data in laboratory tests and patient files, were examined. In the study, demographic characteristics such as age and gender, Rachmilewitz endoscopic activity index, and histopathological activity were determined. In the laboratory results of the patients, CRP, albumin, hemoglobin, leukocytes, neutrophils, monocytes, lymphocytes, thrombocyte and sedimentation values were examined. Results and Conclusion: When the patients were evaluated in terms of histological activity, those with active colitis had CRP (p<0,001), CRP/albumin (p<0,001), leukocytes (p=0,004), neutrophils (p=0,003), monocytes (p=0,009), thrombocyte (p<0,001) and sedimentation (p=0.001) values were found to be significantly higher than those without histologically active colitis, while albumin (p<0,001) and hemoglobin (p=0,031) values were found to be significantly lower. Those with endoscopically active colitis (EAI?4) CRP (p<0,001), CRP/albumin (p<0,001), leukocytes (p=0,001), neutrophils (p=0,001), monocytes (p=0,024), platelets (p=0,002) and sedimentation (p=0,001) values were found to be significantly higher than those in remission endoscopically (EAI<4), and albumin (p=0,001) values were found to be significantly lower. It was observed that there was a positive and significant correlation between endoscopic activity and histological activity and the CRP/albumin ratio. The cut-off point was found to be 0,08 according to the ROC analysis performed on the CRP/albumin value according to the presence of active colitis. The sensitivity at this cut-off point was 75%, and the specificity was 96,67%. The positive predictive value was 97,06%, and the negative predictive value was 72,46%. Keywords: Ulcerative colitis, CRP/Albumin ratio, endoscopic activity
Açıklama
Anahtar Kelimeler
İç Hastalıkları, Internal diseases
