Bronchiectasis: Retrospective Analysis of Clinical and Pathological Findings in a Tertiary-Care Hospital

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dc.authoridTurkmen, Samdanci, Emine/0000-0002-0034-5186
dc.authoridAKATLI, AYSE NUR/0000-0002-9677-2456
dc.authoridCelik, Muhammet Reha/0000-0001-8461-2909
dc.authoridULUTAS, HAKKI/0000-0001-9603-7323
dc.authorwosidTurkmen, Samdanci, Emine/ABH-4716-2020
dc.authorwosidAKATLI, AYSE NUR/ABH-4455-2020
dc.contributor.authorAkatli, Ayse Nur
dc.contributor.authorUlutas, Hakki
dc.contributor.authorSamdanci, Emine Turkmen
dc.contributor.authorCelik, Muhammet Reha
dc.date.accessioned2024-08-04T20:52:03Z
dc.date.available2024-08-04T20:52:03Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground. Bronchiectasis is still a challenging chronic lung disease in developing countries. Patients with bronchiectasis can also have pulmonary hypertension. There are sparse data on the prevalence of pulmonary hypertension in patients with bronchiectasis. Materials and methods. Archived H&E-stained slides of 141 patients histopathologically diagnosed with bronchiectasis were reevaluated. Cases were categorized into 4 subgroups based on histology: tubular, varicose, follicular, and cystic. In addition, concomitant histopathological changes were also reevaluated. For patients with available CT sections, main, right, and left pulmonary artery (PA) diameters and PA/aorta ratio were measured with regard to pulmonary hypertension. Results. Of the cases, 70% (n = 89) were female and 30% (n = 52) were male, with a mean age of 36.58 in females and 33.84 in males. Histopathologically, 43% (n = 68) of the cases showed follicular, 37% (n = 59) showed varicose, 35% (n = 56) showed tubular, and 28% (n = 45) showed cystic bronchiectasis morphology. All cases showed chronic inflammation, fibrosis, muscle destruction, and cartilage destruction. Aspergillus were present in 11% of the cases showing cystic morphology. Approximately 17% of the cases (n = 24) were found to have neuroendocrine cell proliferations. In cases with medial hypertrophy, a statistically significant increase in the left pulmonary artery diameter was radiologically determined. Conclusions. Medial hypertrophy was found to be significant with regard to indicating a radiological increase in left pulmonary artery diameter. Vascular changes observed in bronchiectasis cases and the presence of neuroendocrine cell proliferations should be specified in pathology reports, and aspergilloma should be carefully investigated in cases with predominant cystic morphology.en_US
dc.identifier.doi10.1155/2022/8773204
dc.identifier.issn1368-5031
dc.identifier.issn1742-1241
dc.identifier.pmid35685600en_US
dc.identifier.scopus2-s2.0-85131708041en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1155/2022/8773204
dc.identifier.urihttps://hdl.handle.net/11616/100710
dc.identifier.volume2022en_US
dc.identifier.wosWOS:000778914300026en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-Hindawien_US
dc.relation.ispartofInternational Journal of Clinical Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPulmonary-Hypertensionen_US
dc.subjectTumorletsen_US
dc.titleBronchiectasis: Retrospective Analysis of Clinical and Pathological Findings in a Tertiary-Care Hospitalen_US
dc.typeArticleen_US

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