The use of silver nitrate for chemical de-epithelialization and urothelialization of intestine in a rabbit model of augmentation cystoplasty

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dc.authoridUĞURALP, SEMA/0000-0002-7628-0550;
dc.authorwosidUĞURALP, SEMA/ABH-6309-2020
dc.authorwosidGürbüz, Necla/H-8965-2018
dc.contributor.authorDemirbilek, S
dc.contributor.authorUguralp, S
dc.contributor.authorGürbüz, N
dc.contributor.authorSezgin, N
dc.contributor.authorKirimlioglu, H
dc.date.accessioned2024-08-04T20:13:27Z
dc.date.available2024-08-04T20:13:27Z
dc.date.issued2003
dc.departmentİnönü Üniversitesien_US
dc.description.abstractUrinary tract reconstruction using bowel segments can result in complications such as electrolyte abnormalities, infections, stones and cancer. Intestinal mucosa is the primary site responsible for these complications. De-epithelialization of the mucosa and subsequent urothelialization might alleviate these problems. We recently reported our success in de-epithelialization and subsequent uroepithelialization of intestinal segments using 10 g/100 ml AgNO3 solution in a rat model of augmentation. In this study, chemical de-epithelialization of a colonic segment was attempted using 10 g/100 ml AgNO3 solution in a rabbit model of augmentation. Sigmoid cystoplasty was performed in 20 male New Zealand rabbits using a 6 cm patch of sigmoid colon. There were two groups, including one group of five rabbits (control, group 1) that underwent augmentation alone, while another group (15 rabbits, treatment group or group 2) was treated with 10g/100 ml AgNO3 solution before augmentation. Control rabbits were killed at the week 8 of experimentation. Treatment rabbits were killed at 2-, 4-, 6- and 8-week intervals. Immediately before augmentation and at the end of the 8 week experimental period each rabbit underwent cystometry. De-epithelialization of the bowel epithelium without urothelialization was apparent in the treatment rabbits killed at 2 and 4 weeks. Histological analysis revealed almost complete urothelialization of the augmented sections treated with 10 g/100 ml AgNO3 solution at the end of the 6 and 8 week of experimental periods. The preoperative and postoperative bladder capacities increased substantially in all groups. There was no obvious histologic difference in the amount of collagen present in the augmented tissues in any of the experimental groups. The present study confirmed that the treatment of intestinal segments with 10g/100 ml AgNO3 solution led to chemical de-epithelialization and urothelialization of the augmented segments. This procedure could, theoretically, have applications to human surgery.en_US
dc.identifier.doi10.1007/s00240-003-0311-8
dc.identifier.endpage241en_US
dc.identifier.issn0300-5623
dc.identifier.issn1434-0879
dc.identifier.issue4en_US
dc.identifier.pmid12802541en_US
dc.identifier.scopus2-s2.0-0141680523en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage236en_US
dc.identifier.urihttps://doi.org/10.1007/s00240-003-0311-8
dc.identifier.urihttps://hdl.handle.net/11616/93623
dc.identifier.volume31en_US
dc.identifier.wosWOS:000184902700003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofUrological Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbladderen_US
dc.subjectaugmentationen_US
dc.subjectintestinal de-epithelializationen_US
dc.subjectsilver nitrateen_US
dc.subjectrabbitsen_US
dc.titleThe use of silver nitrate for chemical de-epithelialization and urothelialization of intestine in a rabbit model of augmentation cystoplastyen_US
dc.typeArticleen_US

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