The beneficial effects of 18?-glycyrrhetinic acid on the experimental autoimmune encephalomyelitis (EAE) in C57BL/6 mouse model

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dc.authoridTaşlidere, Aslı Cetin/0000-0003-3902-3210
dc.authoridbasak, nese/0000-0001-5566-8321
dc.authoridozcan, abdulcemal/0000-0002-6759-7556
dc.authoridKamisli, Suat/0000-0003-4281-3301
dc.authorwosidTaşlidere, Aslı Cetin/AAB-3979-2021
dc.authorwosidTaşlıdere, Aslı/ABI-8274-2020
dc.authorwosidbasak, nese/ABH-5495-2020
dc.authorwosidKamisli, Suat/JVN-4663-2024
dc.authorwosidozcan, abdulcemal/B-1348-2008
dc.authorwosidKamisli, Suat/JZT-8388-2024
dc.authorwosidKamisli, Suat/AAC-2706-2021
dc.contributor.authorKamisli, Suat
dc.contributor.authorCiftci, Osman
dc.contributor.authorTaslidere, Asli
dc.contributor.authorTurkmen, Nese Basak
dc.contributor.authorOzcan, Cemal
dc.date.accessioned2024-08-04T20:45:21Z
dc.date.available2024-08-04T20:45:21Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim: The aim of this study was to investigate the beneficial effects of 18 beta-glycyrrhetinic acid (GA) on the experimental allergic encephalomyelitis (EAE) in C57BL/6 mice. GA is a natural substance found in the root of licorice and is used in traditional Chinese medicine. It has many pharmacological activities such as antioxidant, anti-inflammatory, and anti-cancer effects. Materials and methods: A total of 40 C57BL/6 mice were divided equally into four groups: (1) Control, (2) EAE, (3) GA and (4) GAthornEAE. 14 days after induction of EAE with MOG35-55 and pertussis toxin, mice were treated with GA at doses of 100 mg/kg/day for 7 days intraperitoneally. Results: To our results, oxidative stress and lipid peroxidations (elevated TBARS levels, decreased GPx, SOD, CAT, and GSH levels) were significantly (p<. 01) increased, causing EAE in brain tissue. Also, histopathological damage (Caspase-3 and IL-17 activity, p <=.01) and cytokine levels (TNF-alpha and IL-1 beta, p<. 01) were induced with EAE in mice brain tissue. On the other hand, GA treatment significantly (p<. 01) reversed oxidative histological and immunological alterations caused by EAE. Conclusions: In conclusion, the GA treatment can protect the brain tissue against EAE in mice with its antioxidant and anti-inflammatory properties.en_US
dc.identifier.doi10.1080/08923973.2018.1490318
dc.identifier.endpage352en_US
dc.identifier.issn0892-3973
dc.identifier.issn1532-2513
dc.identifier.issue4en_US
dc.identifier.pmid30052483en_US
dc.identifier.scopus2-s2.0-85050989401en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage344en_US
dc.identifier.urihttps://doi.org/10.1080/08923973.2018.1490318
dc.identifier.urihttps://hdl.handle.net/11616/98413
dc.identifier.volume40en_US
dc.identifier.wosWOS:000444439100013en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofImmunopharmacology and Immunotoxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEAEen_US
dc.subject18 beta-glycyrrhetinic aciden_US
dc.subjectC57BL/6en_US
dc.subjectmultiple sclerosisen_US
dc.subjectTNF-alphaen_US
dc.titleThe beneficial effects of 18?-glycyrrhetinic acid on the experimental autoimmune encephalomyelitis (EAE) in C57BL/6 mouse modelen_US
dc.typeArticleen_US

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