Protective effects of melatonin on renal failure in pinealectomized rats

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dc.authorid9217en_US
dc.contributor.authorParlakpınar, Hakan
dc.contributor.authorAcet, Hacı Ahmet
dc.contributor.authorGül, Mehmet
dc.contributor.authorAltınöz, Eyüp
dc.contributor.authorEşrefoğlu, Mukaddes
dc.contributor.authorÇolak, Cemil
dc.date.accessioned2017-08-22T06:24:40Z
dc.date.available2017-08-22T06:24:40Z
dc.date.issued2007
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim: The purpose of the current study was to investigate the effects melatonin on renal function. Methods: The histological appearance of the kidney and malondialdehyde, nitric oxide, glutathione and superoxide dismutase contents were determined. Serum creatinine and blood urea nitrogen levels were also assayed. Rats were divided as: Sham, pinealectomized (Px) and pinealectomized and treated with melatonin. Results: In Px group, malondialdehyde and nitric oxide levels were elevated when compared with the sham group. The Px group exhibited reduced superoxide dismutase activity and glutathione content. All of these harmful changes were restored by melatonin. Melatonin also ameliorated serum creatinine and blood urea nitrogen levels related to renal injury. The score for glomerular, tubular and interstitial changes was significantly higher in the Px group. Melatonin supplementation significantly reduced these parameters. Conclusions: This protective effect may be associated with both melatonin’s lipophilic and hydrophilic effects, thus providing on-site protection against free radical mediated damage.en_US
dc.identifier.citationParlakpınar, H. Acet, H. A. Gül, M. Altınöz, E. Eşrefoğlu, M. Çolak, C. (2007). Protective effects of melatonin on renal failure in pinealectomized rats. International Journal of Urology. 14; 743-748.en_US
dc.identifier.doi10.1111/j.1442-2042.2007.01806.xen_US
dc.identifier.endpage748en_US
dc.identifier.issn09198172
dc.identifier.startpage743en_US
dc.identifier.urihttps://hdl.handle.net/11616/7663
dc.identifier.volume14en_US
dc.language.isoenen_US
dc.publisherInternational Journal of Urologyen_US
dc.relation.ispartofInternational Journal of Urologyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAgingen_US
dc.subjectKidneyen_US
dc.subjectMelatoninen_US
dc.subjectPineal glanden_US
dc.subjectRaten_US
dc.subjectReactive oxygen radicalen_US
dc.titleProtective effects of melatonin on renal failure in pinealectomized ratsen_US
dc.typeArticleen_US

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