Fabrication of Oleic Acid Grafted Starch-based Hybrid Carriers for l-Asparaginase Encapsulation

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dc.authoridUlu, Ahmet/0000-0002-4447-6233
dc.authoridAteş, Burhan/0000-0001-6080-229X
dc.authorwosidUlu, Ahmet/L-5180-2016
dc.authorwosidAteş, Burhan/AAA-3730-2021
dc.contributor.authorHafizosmanoglu, Gulsah
dc.contributor.authorUlu, Ahmet
dc.contributor.authorKoytepe, Suleyman
dc.contributor.authorAtes, Burhan
dc.date.accessioned2024-08-04T20:50:51Z
dc.date.available2024-08-04T20:50:51Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this study, artificial red blood cells (RBCs) for immobilization of l-asparaginase are developed. The artificial red blood cells are prepared via a self-assembly method and characterized by various methods. The prepared material shows a small hydrodynamic size of nearly 120 nm and a zeta potential of -7.2 +/- 0.2 mV. After l-asparaginase encapsulation, the particle size is nearly 295 nm and the zeta potential value is -9.8 +/- 0.1. As expected, the immobilized enzyme shows better pH stability and thermal stability than the free enzyme. For instance, at 60 degrees C, the immobilized enzyme maintains 63.5% of the original activity, while the free enzyme retains only 27.6% of the original activity. Furthermore, the immobilized enzyme exhibits excellent reusability and storage stability, retaining 46.1% of its initial activity after 15 reuses. Overall, the developed artificial RBCs can potentially be applied as a novel support for immobilization of l-asparaginase.en_US
dc.description.sponsorshipInonu University Scientific Research Projects Unit [BAP 2016/16]en_US
dc.description.sponsorshipThis work was supported by The Inonu University Scientific Research Projects Unit (Grant No. BAP 2016/16).en_US
dc.identifier.doi10.1002/star.202100152
dc.identifier.issn0038-9056
dc.identifier.issn1521-379X
dc.identifier.issue1-2en_US
dc.identifier.scopus2-s2.0-85119261893en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1002/star.202100152
dc.identifier.urihttps://hdl.handle.net/11616/100312
dc.identifier.volume76en_US
dc.identifier.wosWOS:000720405200001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWiley-V C H Verlag Gmbhen_US
dc.relation.ispartofStarch-Starkeen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectartificial red blood cellsen_US
dc.subjectencapsulationen_US
dc.subjectenzyme immobilizationen_US
dc.subjectl-asparaginaseen_US
dc.subjectstarchen_US
dc.titleFabrication of Oleic Acid Grafted Starch-based Hybrid Carriers for l-Asparaginase Encapsulationen_US
dc.typeArticleen_US

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