Genetic evaluation of severe male factor infertility in Turkey: A cross-sectional study

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dc.authoridKaraer, Abdullah/0000-0002-2010-6211
dc.authoridCeylaner, Serdar/0000-0003-2786-1911
dc.authorwosidKaraer, Abdullah/ABI-4667-2020
dc.contributor.authorCavkaytar, Sabri
dc.contributor.authorBatioglu, Sertac
dc.contributor.authorGunel, Mufit
dc.contributor.authorCeylaner, Serdar
dc.contributor.authorKaraer, Abdullah
dc.date.accessioned2024-08-04T20:35:54Z
dc.date.available2024-08-04T20:35:54Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjective: To determine the frequency, types of chromosomal abnormalities and Y chromosome microdeletions in patients with severe male factor infertility, and the association between clinical background and genetic abnormality. Study design: A total of 322 infertile men; 136 men with severe oligozoospermia (sperm count <5 million/ml) and 196 with nonobstructive azoospermia were studied between April 2004 and November 2006 at the Dr. Zekai Tahir Burak Women's Health Education and Research Hospital, Ankara, Turkey. Blood, semen samples, and testicular biopsies of patients were obtained. Hormonal analysis (follicle-stimulating hormone (FSH), luteinizing hormone (LH), and testosterone levels), semen analysis, karyotype analysis, and PCR screening for Y chromosome microdeletions were performed. Result(s): Forty-eight out of 332 (14%) infertile men had a genetic abnormality. Twenty-four (7.2%) cases with karyotype abnormality were detected. The frequencies of karyotype abnormalities were Klinefelter's syndrome 17/24 (71%), translocation 3/24 (12%), mix gonadal dysgenesis 2/24 (8%), XX male 1/24 (4%), and 46XYY 1/24 (4%). Twenty cases (6%) infertile men had only Y chromosome microdeletions. The frequencies of the deleted areas were azoospermia factor (AZF) c 42%, AZFb 25%, AZFa 21%, AZFb, c 8%, and AZFa, c 4%. Four of the cases with Y chromosome microdeletions also had a concurrent karyotype abnormality. Conclusion(s): All patients with nonobstructive azoospermia and severe oligozoospermia (sperm count <5 million/ml) should undergo genetic screening.en_US
dc.identifier.doi10.3109/14647273.2012.685923
dc.identifier.endpage106en_US
dc.identifier.issn1464-7273
dc.identifier.issue2en_US
dc.identifier.pmid22524445en_US
dc.identifier.scopus2-s2.0-84861357146en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage100en_US
dc.identifier.urihttps://doi.org/10.3109/14647273.2012.685923
dc.identifier.urihttps://hdl.handle.net/11616/95662
dc.identifier.volume15en_US
dc.identifier.wosWOS:000304256900009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherInforma Healthcareen_US
dc.relation.ispartofHuman Fertilityen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAzoospermiaen_US
dc.subjectchromosomal abnormalityen_US
dc.subjectinfertilityen_US
dc.subjectoligozoospermiaen_US
dc.subjectY chromosome microdeletionen_US
dc.titleGenetic evaluation of severe male factor infertility in Turkey: A cross-sectional studyen_US
dc.typeArticleen_US

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