Adrenomedullin: Possible predictor of insulin resistance in women with polycystic ovary syndrome

Basit Öğe Kaydı
dc.authoridYologlu, Saim/0000-0002-9619-3462
dc.authoridkeskin, lezan/0000-0001-8283-4516
dc.authoridYurekli, Muhittin/0000-0002-5830-8564
dc.authoridSahin, Ibrahim/0000-0002-6231-0034
dc.authorwosidYologlu, Saim/ABI-8014-2020
dc.authorwosidkeskin, lezan/HJP-0902-2023
dc.authorwosidŞahin, İbrahim/HHY-8303-2022
dc.authorwosidYurekli, Muhittin/B-4414-2016
dc.authorwosidSahin, Ibrahim/ABI-6050-2020
dc.contributor.authorSahin, I.
dc.contributor.authorCelik, O.
dc.contributor.authorCelik, N.
dc.contributor.authorKeskin, L.
dc.contributor.authorDogru, A.
dc.contributor.authorDogru, I.
dc.contributor.authorYurekli, M.
dc.date.accessioned2024-08-04T20:36:01Z
dc.date.available2024-08-04T20:36:01Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of the study was to investigate adrenomedullin (ADM) levels and its relation with insulin resistance in women with polycystic ovary syndrome (PCOS). Twenty-nine women with PCOS and 29 age- and body mass index (BMI)-matched control subjects were included in the study. PCOS was defined according to criteria by the Rotterdam European Society of Human Reproduction and Embryology/American Society for Reproductive Medicine (ESHRE/ASRM)-sponsored PCOS consensus workshop group. A full clinical and biochemical examination including basal hormones and metabolic profile was performed. Insulin resistance was calculated by using the homeostasis model assessment of insulin resistance index (HOMA-IR). Plasma ADM levels were measured by high performance liquid chromatographic (HPLC) method. Plasma ADM, fasting insulin levels and HOMA-IR were significantly higher in patients with PCOS than the control group. ADM levels were positively correlated with insulin levels and HOMA-IR index. The best cut-off value of ADM levels to identify the presence of insulin resistance (HOMA-IR >= 2.7) was 30.44 ng/ml. Calculated odds ratio of insulin resistance by using logistic regression analysis, as predicted by ADM, was 0.15 (95% confidence interval, 0.037-0.628; p=0.009). In multiple regression analysis, ADM level was an independent predictor of HOMA-IR index. Our finding indicated that ADM levels increased in women with PCOS in accordance with HOMA-IR. ADM could be a significant independent determinant of insulin resistance in women with PCOS. (J. Endocrinol. Invest. 35: 553-556, 2012) (C) 2012, Editrice Kurtisen_US
dc.identifier.doi10.3275/7872
dc.identifier.endpage556en_US
dc.identifier.issn0391-4097
dc.identifier.issn1720-8386
dc.identifier.issue6en_US
dc.identifier.pmid21791966en_US
dc.identifier.scopus2-s2.0-84863966306en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage553en_US
dc.identifier.urihttps://doi.org/10.3275/7872
dc.identifier.urihttps://hdl.handle.net/11616/95725
dc.identifier.volume35en_US
dc.identifier.wosWOS:000310758400002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Endocrinological Investigationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdrenomedullinen_US
dc.subjectPCOSen_US
dc.subjectinsulin resistanceen_US
dc.subjectHOMA indexen_US
dc.titleAdrenomedullin: Possible predictor of insulin resistance in women with polycystic ovary syndromeen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu