Anticancer and Cytotoxic Activities of Some Trigonella Species on MCF-7, L929 and HeLa Cell Lines

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dc.authoridGumushan Aktas, Hatice/0000-0002-6650-184X
dc.authoridTAKIM, KASIM/0000-0003-4631-1982
dc.authoridakan, hasan/0000-0002-3033-4349
dc.authoridDurna Dastan, Sevgi/0000-0003-4946-5602
dc.authorwosidDurna Dastan, Sevgi/F-4682-2017
dc.contributor.authorMojarradgandoukmolla, Shahrokh
dc.contributor.authorAkan, Hasan
dc.contributor.authorKasim, Takim
dc.contributor.authorDastan, Sevgi Durna
dc.contributor.authorAktas, Hatice Gumushan
dc.date.accessioned2024-08-04T20:56:04Z
dc.date.available2024-08-04T20:56:04Z
dc.date.issued2024
dc.departmentİnönü Üniversitesien_US
dc.description.abstractTrigonella filipes Boiss, Trigonella strangulata Boiss., and Trigonella uninata Banks and Sol., are three commonly used species that grow well in Iraq's northern suburbs and are frequently consumed and used in traditional medicine. The current study was planned to assess and identify the active chemicals in these plant species, as well as to analyze their anticancer and antiprofeliration effects in rats treated with alcohol and cholesterol. Plant extracts were tested for oxidative stress index (OSI), total oxidant status (TOS), and total antioxidant status (TAS). Administration of Trigonella foenum-graecum and Trigonella monantha significantly improved these changes in diseased rats. MTT cytotoxicity test was used to investigate the cytotoxic properties of Trigonella filipes, Trigonella strangulata, and Trigonella uncinata plant extracts on three distinct cell lines in varied concentrations (1-10-100-1000 g/mL) after 24 h of incubation. The results were supported that these three plant taxa have high phytochemical compounds that have physiological effects such as inhibit cell proliferation, improving the function of liver and kidney function, and antioxidants effect.en_US
dc.description.sponsorshipHUBAK of Harran University, Sanliurfa, Turkeyen_US
dc.description.sponsorshipThe authors gratefully recognize the HUBAK of Harran University, Sanliurfa, Turkey for partially supporting this project and offering the best facility for research.en_US
dc.identifier.doi10.1134/S1062359023603567
dc.identifier.endpage834en_US
dc.identifier.issn1062-3590
dc.identifier.issn1608-3059
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85195136116en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage829en_US
dc.identifier.urihttps://doi.org/10.1134/S1062359023603567
dc.identifier.urihttps://hdl.handle.net/11616/102036
dc.identifier.volume51en_US
dc.identifier.wosWOS:001236820200003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherPleiades Publishing Incen_US
dc.relation.ispartofBiology Bulletinen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTrigonellaen_US
dc.subjectoxidative stress indexen_US
dc.subjecttotal oxidant statusen_US
dc.subjecttotal antioxidant statusen_US
dc.titleAnticancer and Cytotoxic Activities of Some Trigonella Species on MCF-7, L929 and HeLa Cell Linesen_US
dc.typeArticleen_US

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