Molecular epidemiology of the Bacillus anthracis isolates collected throughout Turkey from 1983 to 2011

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dc.authoridRenders, Duygu Percin/0000-0002-4436-5226
dc.authoridBüyük, Fatih/0000-0003-3278-4834
dc.authoridDoganay, Mehmet/0000-0003-3922-4901
dc.authoridOTLU, BARIS/0000-0002-6220-0521
dc.authoridKarahocagil, Mustafa Kasım/0000-0002-5171-7306
dc.authoridDURMAZ, RIZA/0000-0001-6561-778X
dc.authorwosidÖztürk, Zeynep/GSO-2816-2022
dc.authorwosidRenders, Duygu Percin/AEU-1995-2022
dc.authorwosidBüyük, Fatih/AAZ-1882-2020
dc.authorwosidDURMAZ, Rıza/HJH-4918-2023
dc.authorwosidDoganay, Mehmet/G-4250-2019
dc.authorwosidOTLU, BARIS/ABI-5532-2020
dc.authorwosidKarahocagil, Mustafa Kasım/JVZ-6523-2024
dc.contributor.authorDurmaz, R.
dc.contributor.authorDoganay, M.
dc.contributor.authorSahin, M.
dc.contributor.authorPercin, D.
dc.contributor.authorKarahocagil, M. K.
dc.contributor.authorKayabas, U.
dc.contributor.authorOtlu, B.
dc.date.accessioned2024-08-04T20:36:12Z
dc.date.available2024-08-04T20:36:12Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe main perspective of this study was to determine cross-transmissions amongst anthrax cases and provide detailed information regarding the genotypes of Bacillus anthracis isolates circulating in Turkey. A total of 251 B. anthracis isolates were obtained from human (93 isolates), animal (155 isolates), and environmental (three isolates) samples in various provinces of Turkey. All isolates were susceptible to quinolones, vancomycin, tigecycline, and linezolid, but not to ceftriaxone. Excluding human isolates, one of the animal isolates was found to be resistant to penicillin, erythromycin, and doxycycline. Multiple-locus variable-number tandem repeats analysis including 8 loci (MLVA8) revealed 12 genotypes, in which genotype 43 was observed at the highest frequency (41.8 %), followed by genotype 35 (25.5 %) and genotype 27 (10.4 %). Major subtype A3.a was the predominant cluster, including 86.8 % of the isolates. The MLVA25 analysis for the 251 isolates yielded 62 different genotypes, 33 of which had only one isolate, while the remaining 29 genotypes had 2 to 43 isolates, with a total of 218 isolates (86.9 %). These findings indicate very high cross-transmission rates within anthrax cases in Turkey. The genotypes diagnosed in Turkey are populated in the A major cluster. Penicillin prescribed as the first-choice antibiotic for the treatment of anthrax is still effective.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey [108 S164]en_US
dc.description.sponsorshipThis study was supported by a grant (108 S164) from the Scientific and Technological Research Council of Turkey. The authors thank Dr. Florigio Lista and Dr. Andrea Ciammaruconi from the Histology and Molecular Biology Section, Army Medical and Veterinary Research Center, Via Santo Stefano Rotondo 4, 00184, Rome, Italy, for their help and encouraging suggestions on the MLVA typing protocol.en_US
dc.identifier.doi10.1007/s10096-012-1628-4
dc.identifier.endpage2790en_US
dc.identifier.issn0934-9723
dc.identifier.issue10en_US
dc.identifier.pmid22576652en_US
dc.identifier.scopus2-s2.0-84869099363en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2783en_US
dc.identifier.urihttps://doi.org/10.1007/s10096-012-1628-4
dc.identifier.urihttps://hdl.handle.net/11616/95853
dc.identifier.volume31en_US
dc.identifier.wosWOS:000309214300035en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofEuropean Journal of Clinical Microbiology & Infectious Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTandem-Repeat Analysisen_US
dc.subjectGradient Diffusion Methodsen_US
dc.subjectAntimicrobial Susceptibilityen_US
dc.subjectInfectionen_US
dc.subjectDiversityen_US
dc.titleMolecular epidemiology of the Bacillus anthracis isolates collected throughout Turkey from 1983 to 2011en_US
dc.typeArticleen_US

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