Effects of intracerebroventricular MOTS-c infusion on thyroid hormones and uncoupling proteins

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dc.authoridÇOLAK, CEMİL/0000-0001-5406-098X
dc.authoridözyalın, fatma/0000-0001-6486-6389
dc.authoridTekin, Suat/0000-0002-2757-1802
dc.authoridSandal, Suleyman/0000-0002-8916-3329
dc.authoridBahar, Mehmet Refik/0000-0002-7922-3850
dc.authorwosidÇOLAK, CEMİL/ABI-3261-2020
dc.authorwosidözyalın, fatma/ABA-5258-2020
dc.authorwosidTekin, Suat/KEI-2266-2024
dc.authorwosidSandal, Suleyman/AAA-6388-2021
dc.authorwosidBahar, Mehmet Refik/ABI-6343-2020
dc.contributor.authorBahar, Mehmet Refik
dc.contributor.authorTekin, Suat
dc.contributor.authorBeytur, Asiye
dc.contributor.authorOnalan, Ebru Etem
dc.contributor.authorOzyalin, Fatma
dc.contributor.authorColak, Cemil
dc.contributor.authorSandal, Suleyman
dc.date.accessioned2024-08-04T20:53:40Z
dc.date.available2024-08-04T20:53:40Z
dc.date.issued2023
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThis study was conducted to determine the possible effects of intracerebroventricular MOTS-c infusion on thyroid hormones and uncoupling proteins (UCPs) in rats. Forty male Wistar Albino rats were divided into 4 groups with 10 animals in each group: control, sham, 10 and 100 mu M MOTS-c. Hypothalamus, blood, muscle, adipose tissues samples were collected for thyrotropin-releasing hormone (TRH), UCP1 and UCP3 levels were determined by the RT-PCR and western blot analysis. Serum thyroid hormone levels were determined by the ELISA assays. MOTS-c infusion was found to increase food consumption but it did not cause any changes in the body weight. MOTS-c decreased serum TSH, T3, and T4 hormone levels. On the other hand, it was also found that MOTS-c administration increased UCP1 and UCP3 levels in peripheral tissues. The findings obtained in the study show that central MOTS-c infusion is a directly effective agent in energy metabolism.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [116S744]; Inonu University Scientific Research Projects Unit (BAP) [TYL-2019-2026]en_US
dc.description.sponsorshipThis study was supported by the Scientific and Technological Research Council of Turkey (TUBITAK; Project No: 116S744) and Inonu University Scientific Research Projects Unit (BAP; Project No: TYL-2019-2026).en_US
dc.identifier.doi10.1007/s42977-023-00163-6
dc.identifier.endpage170en_US
dc.identifier.issn2676-8615
dc.identifier.issn2676-8607
dc.identifier.issue1-2en_US
dc.identifier.pmid37067760en_US
dc.identifier.scopus2-s2.0-85153032318en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage159en_US
dc.identifier.urihttps://doi.org/10.1007/s42977-023-00163-6
dc.identifier.urihttps://hdl.handle.net/11616/101301
dc.identifier.volume74en_US
dc.identifier.wosWOS:000970720800001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofBiologia Futuraen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMOTS-cen_US
dc.subjectThyroid hormonesen_US
dc.subjectEnergy useen_US
dc.subjectUCP1en_US
dc.subjectUCP3en_US
dc.titleEffects of intracerebroventricular MOTS-c infusion on thyroid hormones and uncoupling proteinsen_US
dc.typeArticleen_US

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