Protective Effects of Phoenixin-14 Administration Against Renal Ischemia/Reperfusion Injury in Rats

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dc.contributor.authorOz, Samet
dc.contributor.authorBahar, Mehmet Refik
dc.contributor.authorSekerci, Guldeniz
dc.contributor.authorTaslidere, Asli
dc.contributor.authorTekin, Suat
dc.date.accessioned2026-04-04T13:37:39Z
dc.date.available2026-04-04T13:37:39Z
dc.date.issued2025
dc.departmentİnönü Üniversitesi
dc.description.abstractPhoenixin (PNX), identified in the rat hypothalamus in 2013, has two bioactive isoforms with 14 and 20 amino acids. Initially studied for its role in reproductive regulation, research has since shown that PNX also prevents visceral pain, enhances memory, and aids heart tissue recovery. However, its role in kidney tissue remains unclear. Due to its antioxidant properties, PNX may help reduce oxidative stress and cellular damage in organs. This study was designed to determine the potential protective effects of Phoenixin-14 (PNX-14) against renal ischemia/reperfusion (I/R)-induced injury in rats. 40 male Wistar Albino rats were divided into four groups: Control, I/R, PNX-14 (50 mu g/kg), and PNX-14 (100 mu g/kg) (n = 10). All groups except the control group underwent 45 min of bilateral ischemia followed by 24 h of reperfusion. PNX-14 (50 and 100 mu g/kg, intraperitoneally) was administered 1 h before induction of ischemia. Both doses of PNX-14 reduced the levels of acute kidney injury markers (blood urea nitrogen and creatinine) in blood tissue (p < 0.05). PNX-14 increased the activity of antioxidant enzymes (superoxide dismutase and catalase) and the levels of glutathione, while reducing malondialdehyde (p < 0.05). Histological evaluation of the I/R group revealed significant histopathological findings, and it was found that PNX-14 administration improved these histological damages (p < 0.05). These results suggest that PNX-14 provides protection against renal injury induced by I/R. After further studies, PNX-14 may be a new therapeutic strategy to prevent renal I/R injury.
dc.identifier.doi10.1002/jbt.70200
dc.identifier.issn1095-6670
dc.identifier.issn1099-0461
dc.identifier.issue3
dc.identifier.pmid40025799
dc.identifier.scopus2-s2.0-86000119094
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1002/jbt.70200
dc.identifier.urihttps://hdl.handle.net/11616/109967
dc.identifier.volume39
dc.identifier.wosWOS:001440399900001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Biochemical and Molecular Toxicology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250329
dc.subjectAcute Kidney Injury
dc.subjectAntioxidant Activity
dc.subjectOxidative Stress
dc.subjectPhoenixin-14
dc.titleProtective Effects of Phoenixin-14 Administration Against Renal Ischemia/Reperfusion Injury in Rats
dc.typeArticle

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