Protective effect of ipratropium bromide on bronchoconstriction induced by sulfur dioxide exposure during apricot sufurization processes that causes asthma-like syndrome in agricultural environment

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dc.authoridKilic, Talat/0000-0001-8125-9062;
dc.authorwosidKoksal, Nurhan/AAA-3249-2022
dc.authorwosidKilic, Talat/ABI-4457-2020
dc.authorwosidKöksal, Nurhan/AAG-5849-2021
dc.contributor.authorYildirim, Z
dc.contributor.authorKilic, T
dc.contributor.authorKoksal, N
dc.contributor.authorKotuk, M
dc.date.accessioned2024-08-04T20:13:46Z
dc.date.available2024-08-04T20:13:46Z
dc.date.issued2005
dc.departmentİnönü Üniversitesien_US
dc.description.abstractWe previously showed that apricot sulfurization workers are exposed to high concentrations of sulfur dioxide (SO2) resulting in an asthmalike syndrome. The aim of this study was to investigate whether pre-treatment of ipratropium bromide protects bronchoconstriction induced by SO2 exposure during apricot sulfurization processes that causes asthma-like syndrome. Firstly, pulmonary function tests were measured before and immediately after SO2 exposure due to processes of apricot sulfurization in 21 healthy volunteer apricot sulfurization workers who did not use any medication in apricot farms. One week later, same measurements were repeated in the same workers when they were working in same farm but they were administered two puffs of ipratropium bromide (20 mu g per dose) before 30 min second SO2 exposure for protection Of SO2-induced bronchoconstriction. Occupational SO2 exposure caused significant decrement in forced vital capacity (FVC), forced expiratory volume (FEVI) and forced mid-expiratory flow rate (FEF25-75%) in the worker and these decrements were prevented by ipratropium bromide given 30 min before SO2 exposure. This result suggests that pre-treatment of ipratropium bromide protects SO2-induced bronchoconstriction in healthy worker during apricot sulfurization processes that causes asthma-like syndrome in agricultural environment. (c) 2005 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.phrs.2004.12.004
dc.identifier.endpage482en_US
dc.identifier.issn1043-6618
dc.identifier.issue5en_US
dc.identifier.pmid15749463en_US
dc.identifier.scopus2-s2.0-14644429068en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage479en_US
dc.identifier.urihttps://doi.org/10.1016/j.phrs.2004.12.004
dc.identifier.urihttps://hdl.handle.net/11616/93830
dc.identifier.volume51en_US
dc.identifier.wosWOS:000227958000011en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAcademic Press Ltd- Elsevier Science Ltden_US
dc.relation.ispartofPharmacological Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectasthma-like syndromeen_US
dc.subjectapricot sulfurizationen_US
dc.subjectsulfur dioxideen_US
dc.subjectipratropium bromideen_US
dc.titleProtective effect of ipratropium bromide on bronchoconstriction induced by sulfur dioxide exposure during apricot sufurization processes that causes asthma-like syndrome in agricultural environmenten_US
dc.typeArticleen_US

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