Comprehensive Analysis of Long-term Splenic Volume Changes in Pediatric Liver Transplant Patients: Does It Correlate With Adverse Graft Outcomes?

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dc.authoridKutluturk, Koray/0000-0002-7030-4953
dc.authoridYilmaz, Sezai/0000-0002-8044-0297
dc.authoridDOGAN, SAIT MURAT/0000-0001-8840-4365
dc.authoridKARAKAS, SERDAR/0000-0001-8314-7806
dc.authoridOkut, Gokalp/0000-0002-3641-5625
dc.authoridSAHIN, TEVFIK TOLGA/0000-0002-9132-6115
dc.authorwosidKutluturk, Koray/S-5493-2019
dc.authorwosidYilmaz, Sezai/ABI-2323-2020
dc.authorwosiddogan, Gulec mert/AAT-5815-2021
dc.authorwosidDOGAN, SAIT MURAT/AAP-7924-2021
dc.authorwosidOkut, Gokalp/GRE-9040-2022
dc.authorwosidKARAKAS, SERDAR/AAB-3219-2021
dc.authorwosidSAHIN, TEVFIK TOLGA/W-2539-2017
dc.contributor.authorDogan, Gulec Mert
dc.contributor.authorDogan, Sait Murat
dc.contributor.authorOkut, Gokalp
dc.contributor.authorKarakas, Serdar
dc.contributor.authorKutluturk, Koray
dc.contributor.authorUlubaba, Hilal Er
dc.contributor.authorSahin, Tevfik Tolga
dc.date.accessioned2024-08-04T20:48:55Z
dc.date.available2024-08-04T20:48:55Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives. Splenomegaly and hypersplenism caused by liver failure increase the mortality and morbidity of patients even after liver transplantation if they do not regress. We evaluated the relation of splenic volume change and transplanted liver function. Material and Methods. A total of 59 of 207 pediatric patients who had liver transplantation between 2013 and 2018 in our institute were evaluated. The relation of spleen volume changes (splenic volume to standard splenic volume ratio [SV/SSV]) were measured at 0, 1, 6, 12, 24, and 36 months of follow-up by constructing electronic three-dimensional structure of the spleen at dynamic computed tomography (CT), and the course of liver functions were evaluated. Results. The SV/SSV ratio decreases in the first postoperative 6 months. After 6 months, SV increases and SV/SSV increases gradually. In a normal functioning graft, SV/SSV significantly decreased in all time points (P < .001). In patients with adverse events, SV/SSV started to increase after 6 months. In patients with fulminant hepatic failure, SV/SSV started to increase after postoperative 6 months. Adverse events in patients with fulminant hepatic failure were more than the patients with chronic liver disease (58% vs 28%). There was an inverse correlation between SV/SSV and thrombocyte levels (P < .001). Conclusions. SV/SSV seems to be correlated to the adverse events (ie, rejection). Together with thrombocyte levels, it can be used as a noninvasive test for follow-up of transplant patients in terms of adverse events in graft function.en_US
dc.identifier.doi10.1016/j.transproceed.2020.08.031
dc.identifier.endpage110en_US
dc.identifier.issn0041-1345
dc.identifier.issn1873-2623
dc.identifier.issue1en_US
dc.identifier.pmid32919802en_US
dc.identifier.scopus2-s2.0-85090718534en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage104en_US
dc.identifier.urihttps://doi.org/10.1016/j.transproceed.2020.08.031
dc.identifier.urihttps://hdl.handle.net/11616/99530
dc.identifier.volume53en_US
dc.identifier.wosWOS:000648560100014en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofTransplantation Proceedingsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHypersplenismen_US
dc.subjectSizeen_US
dc.titleComprehensive Analysis of Long-term Splenic Volume Changes in Pediatric Liver Transplant Patients: Does It Correlate With Adverse Graft Outcomes?en_US
dc.typeArticleen_US

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