Testosterone and DHEA-S levels with chronic tic disorder in children

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dc.authoriderbay, lale gönenir/0000-0002-9969-3016
dc.authoridÖzcan, Özlem/0000-0003-3267-2648
dc.authoridKUTUK, MERYEM/0000-0002-2918-7871
dc.authoridUyumlu, Ayşe Burçin/0000-0001-9517-9274
dc.authoridkartalcı, şükrü/0000-0003-2560-0355
dc.authoridÇALIŞKAN DEMİR, ARZU/0000-0002-0835-380X
dc.authorwosiderbay, lale gönenir/AAE-6285-2019
dc.authorwosidÖzcan, Özlem/ABH-9167-2020
dc.authorwosidKUTUK, MERYEM/AAI-9626-2021
dc.authorwosidUyumlu, Ayşe Burçin/ABH-5573-2020
dc.authorwosidkartalcı, şükrü/ABI-1106-2020
dc.authorwosidÇALIŞKAN DEMİR, ARZU/ABG-9592-2020
dc.contributor.authorErbay, Lale Gonenir
dc.contributor.authorKartalci, Sukru
dc.contributor.authorOzcan, Ozlem Ozel
dc.contributor.authorDemir, Arzu Caliskan
dc.contributor.authorUyumlu, Ayse Burcin
dc.contributor.authorKutuk, Meryem Ozlem
dc.date.accessioned2024-08-04T20:41:39Z
dc.date.available2024-08-04T20:41:39Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe neurobiological basis of tic disorders is thought to be a series of interactions including genetic, environmental and gender related factors. Being male is thought to be an especially important risk factor in the pathogenesis of tics. Our aim in this study was to investigate gender-related hormones such as testosterone, dehydroepiandrosterone sulfate (DHEA-S) and cortisol in tic patients. A total of 26 patients who had not entered puberty and had been diagnosed with chronic tic disorder and 25 healthy children were included in the study, Serum total testosterone, cortisol and DHEA-S levels were measured and the relationship with clinical data was investigated. The testosterone and DHEA-S levels of the patient group were higher than that of the control group (P=0.019, P=0.025) but no statistical difference was found between the cortisol levels (P=0.642). No statistical correlation was found between total tic severity, general disturbance, movement tic subscale scores and the DHEA-S (P=0.77, P=0.45, P=0.819 respectively) and testosterone levels (P=0.954, P=0.669, P=0.909 respectively). The results of this study reveal an elevation of testosterone and DHEA-S levels in patients. Future studies with a larger number of patients are likely to help elucidate the importance of these androgens in tic disorder. (C) 2016 Elsevier Inc. All rights reserved.en_US
dc.identifier.doi10.1016/j.jocrd.2016.04.002
dc.identifier.endpage76en_US
dc.identifier.issn2211-3649
dc.identifier.scopus2-s2.0-84962821710en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage73en_US
dc.identifier.urihttps://doi.org/10.1016/j.jocrd.2016.04.002
dc.identifier.urihttps://hdl.handle.net/11616/97260
dc.identifier.volume9en_US
dc.identifier.wosWOS:000375824000011en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofJournal of Obsessive-Compulsive and Related Disordersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTic disorderen_US
dc.subjectTourette's syndromeen_US
dc.subjectTestosteroneen_US
dc.subjectDHEA - Sen_US
dc.titleTestosterone and DHEA-S levels with chronic tic disorder in childrenen_US
dc.typeArticleen_US

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