GLP 1 and GLP 2 levels indiabetic ketoacidosis
| dc.authorid | 10983 | en_US |
| dc.contributor.author | Akıncı, Ayşehan | |
| dc.contributor.author | Aydın, Özgür | |
| dc.contributor.author | Özerol, Halil İbrahim | |
| dc.date.accessioned | 2017-07-14T13:23:57Z | |
| dc.date.available | 2017-07-14T13:23:57Z | |
| dc.date.issued | 2009 | |
| dc.department | İnönü Üniversitesi | en_US |
| dc.description | JCRPE | en_US |
| dc.description.abstract | Objective: The aim of this study was to investigate whether insulin deficiency and increased catabolism may have a role in the regulation of plasma glucagon-like peptide (GLP)-1 and GLP- 2 levels in children with diabetic ketoacidosis (DKA) and whether insulin treatment may affect the levels of these polypeptides. Methods: Plasma GLP-1 and -2 levels were measured in 24 patients with DKA aged 8 to 14 years before insulin infusion (time 0), when ketonemia and acidosis disappeared (time 1), and when weight gain started (time 2). Eighteen healthy children aged 8 to 14 years constituted the control group. Results: At time 0, mean plasma GLP-1 and GLP-2 levels were significantly elevated in the patients compared with the control group (p<0.05 and p<0.01, respectively). At time 1 when ketonemia and acidosis disappeared, GLP-1 and GLP-2 levels decreased significantly from the initial levels (p<0.05 and p<0.01, respectively). At this time, while GLP-1 level was not different from that of the controls, GLP-2 level was higher than that of the controls (p<0.05). GLP-1 and-2 levels did not show any significant differences between the patients and controls when weight gain started (time 2). Conclusion: Our results show that DKA is associated with increased plasma GLP-1 and -2 concentrations. Effective fluid and insulin treatment resulted in a significant decrease in plasma GLP- 1 and -2 levels. This may be due to the negative feedback effect of insulin on the production of these polypeptides. | en_US |
| dc.identifier.citation | AKINCI, A., AYDIN, Ö., & HALİL İBRAHİM, Ö. (2009). GLP 1 and GLP 2 levels indiabetic ketoacidosis. JCRPE, 3, 21–24. | en_US |
| dc.identifier.doi | 10.4274/jcrpe.2023 | en_US |
| dc.identifier.endpage | 24 | en_US |
| dc.identifier.issue | 0 | en_US |
| dc.identifier.startpage | 21 | en_US |
| dc.identifier.uri | https://hdl.handle.net/11616/7372 | |
| dc.identifier.volume | 3 | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | JCRPE | en_US |
| dc.relation.ispartof | JCRPE | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.subject | Glucagon-like peptide | en_US |
| dc.subject | Diabetic ketoacidosis | en_US |
| dc.subject | Diabetes mellitus | en_US |
| dc.title | GLP 1 and GLP 2 levels indiabetic ketoacidosis | en_US |
| dc.type | Article | en_US |
