Effects of Molsidomine against Doxorubicin-Induced Cardiotoxicity in Rats

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dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridAkaycan, Jülide/0000-0002-9174-6777
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoriddisli, olcay murat/0000-0002-9699-4817
dc.authoridPolat, Alaadin/0000-0002-6920-3856
dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authoridSarihan, Mehmet Ediz/0000-0002-1266-4213
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidAkaycan, Jülide/ABI-2397-2020
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosiddisli, olcay murat/ABI-3289-2020
dc.authorwosidColak, M. Cengiz/ABI-3394-2020
dc.authorwosidPolat, Alaadin/AAA-7171-2021
dc.authorwosidVardı, Nigar/C-9549-2018
dc.contributor.authorDisli, O. M.
dc.contributor.authorSarihan, E.
dc.contributor.authorColak, M. C.
dc.contributor.authorVardi, N.
dc.contributor.authorPolat, A.
dc.contributor.authorYagmur, J.
dc.contributor.authorTamtekin, B.
dc.date.accessioned2024-08-04T20:37:53Z
dc.date.available2024-08-04T20:37:53Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose: To explore the protective and curative effects of molsidomine (MOL) on doxorubicin (DOX)-induced cardiac damage in the in vivo rat heart. Methods: Forty rats were randomized into five groups (n = 8): (1) the control group; (2) the MOL group (10 mg/kg for 21 days); (3) the DOX group (a single dose of 20 mg/kg); (4) the DOX + MOL group (3 days after the single dose of DOX, 10 mg/kg MOL continued for 21 days), and (5) the MOL + DOX group (24 h after a 21-day regimen of 10 mg/kg MOL, a single dose of DOX). The rats were monitored for mean arterial blood pressure, heart rate, O-2 saturation, and electrocardiography. Heart tissue levels of malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH), and nitric oxide (NO) were determined. Results: Blood pressure and O-2 saturation values indicated a significant decrease in the DOX group compared with the control group. T negativity was observed in 4 of 8 rats in the DOX group, in 1 of 8 rats in the DOX + MOL group, and in 4 of 8 rats in the MOL + DOX group. MDA levels were significantly higher in the DOX group. SOD, GSH, and NO levels were significantly lower in the DOX group compared with the other groups. There was no statistically significant difference in the CAT levels in any of the study groups compared with controls. DOX treatment induced morphological alterations, such as disorganization of cardiomyocytes, loss of myofibrils, and cytoplasmic vacuolization in the heart. On the other hand, histological damage was significantly reduced in the DOX + MOL and MOL + DOX groups. Conclusion: This study implies that there are cardioprotective effects of MOL on DOX-induced cardiotoxicity. (C) 2013 S. Karger AG, Baselen_US
dc.identifier.doi10.1159/000354807
dc.identifier.endpage90en_US
dc.identifier.issn0014-312X
dc.identifier.issn1421-9921
dc.identifier.issue1-2en_US
dc.identifier.pmid24157421en_US
dc.identifier.scopus2-s2.0-84886074750en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage79en_US
dc.identifier.urihttps://doi.org/10.1159/000354807
dc.identifier.urihttps://hdl.handle.net/11616/96245
dc.identifier.volume51en_US
dc.identifier.wosWOS:000327768200009en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofEuropean Surgical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMolsidomineen_US
dc.subjectHearten_US
dc.subjectDoxorubicinen_US
dc.subjectCardiotoxicityen_US
dc.titleEffects of Molsidomine against Doxorubicin-Induced Cardiotoxicity in Ratsen_US
dc.typeArticleen_US

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