Evaluation by train of four vecuronium induced neuromuscular block during sevoflurane and isoflurane anaesthesia

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dc.authorscopusid6701613323
dc.authorscopusid6603245381
dc.authorscopusid7004486274
dc.contributor.authorTogal T.
dc.contributor.authorGedik E.
dc.contributor.authorErsoy M.O.
dc.date.accessioned2024-08-04T20:00:37Z
dc.date.available2024-08-04T20:00:37Z
dc.date.issued1999
dc.departmentİnönü Üniversitesien_US
dc.description.abstractVolatile anaesthetics enhance the action of neuromuscular blockade to various degrees, the purpose of the present study is to compare the effects of volatile anaesthetics (isoflurane and sevoflurane) on the onset time of the neuromuscular blockade by vecuronium. Following approval from the ethic committee, 20 ASA I-II patients of either sex, aged 17-61 years old, were scheduled for elective laparoscopic surgery. Patients were randomly allocated to two groups. While induction of anaesthesia was performed with thiopentone 6 mg/kg and vecuronium 0.07 mg/kg, fentanyl 1 ?g/kg, lidocaine 1 mg/kg and maintained by 66/33 % N2O/O2 and sevoflurane (1.7 %) group I and isoflurane (1.2 %) in group II. The EMG response of the adductor pollicis was monitored by TOF-Guard stimulator (Biometer) at 20s intervals after train of four (TOF) stimulation of the ulnar nerve. Following intubation, whenever T1 returned to 25 % control additional doses of vecuronium was given (0.02 mg/kg). Supramaximal stimuli, duration 0.2 miliseconds and frequency 2 Hz were delivered at 20 seconds intervals to the ulnar nerve. The onset time (T1 max), duration of block (T1 25 %), time to maximal block after the second dose (T2 max), duration of action of maintenance doses (T2 25 %) and recovery times (T2 75 % - 25 %) were the parameters measured. There were no statistical significant differences between two volatile anaesthetics effects. In conclusion the effects of sevoflurane are similar to those of isoflurane on the neuromuscular block produced by vecuronium.en_US
dc.identifier.endpage51en_US
dc.identifier.issn1016-5150
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-0032934993en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage48en_US
dc.identifier.urihttps://hdl.handle.net/11616/90847
dc.identifier.volume27en_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.relation.ispartofTurk Anesteziyoloji ve Reanimasyonen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIsofluraneen_US
dc.subjectSevofluraneen_US
dc.subjectVecuronium bromideen_US
dc.titleEvaluation by train of four vecuronium induced neuromuscular block during sevoflurane and isoflurane anaesthesiaen_US
dc.title.alternativeSevofluran ve isofluran anestezilerinde vekuronyum noromuskuler blokajinin dortlu yanitlar ile degerlendirilmesien_US
dc.typeArticleen_US

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