Late onset hyponatremia in preterm newborns: is the sodium content of human milk fortifier insufficient?

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dc.authoridOGUZ, SUNA SERIFE/0000-0002-1870-0983
dc.authorwosidGökçe, İsmail Kürşad/ABI-8128-2020
dc.authorwosidOGUZ, SUNA SERIFE/GWZ-7382-2022
dc.contributor.authorGokce, Ismail Kursad
dc.contributor.authorOguz, Serife Suna
dc.date.accessioned2024-08-04T20:45:25Z
dc.date.available2024-08-04T20:45:25Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIntroduction: In this study, we aimed to define the incidence and time to detection of late onset hyponatremia (LOH) as well as factors affecting its development in preterm newborns. We also aimed to determine the daily sodium requirement of these patients. Methods: We studied a total of 145 very low birth weight infants with a full or nearly full enteral diet and followed them up until discharge. We recorded demographic and clinic characteristics. We measured serum sodium (SNa) levels at least once a week after the second week. We compared infants with LOH with other infants to analyze possible risk factors. Results: Twenty-nine (20%) infants developed LOH in an average of 23.4 +/- 7.8 days. The mean SNa level of these infants was 124.6 +/- 5.6 mmol/L. Logistic regression analysis showed that a birth weight of less than 1000 g, preterm early membrane rupture, and nutrition with fortified human milk alone were risk factors for LOH. The mean daily amount of sodium added to the nutrition of hyponatremic preterm infants was 3.6 +/- 2.1 mmol/L. Subgroup analysis showed that the incidence of LOH was two times higher (39.2%) in infants with a birth weight of less than 1000 g. Conclusion: We observed the development of LOH within three to four weeks in nearly half of preterm infants fed with fortified human milk, especially those with a birth weight of less than 1000 g. We believe that the sodium content of currently used human milk fortifiers should be increased.en_US
dc.identifier.doi10.1080/14767058.2018.1517314
dc.identifier.endpage1202en_US
dc.identifier.issn1476-7058
dc.identifier.issn1476-4954
dc.identifier.issue7en_US
dc.identifier.pmid30149743en_US
dc.identifier.scopus2-s2.0-85053535410en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1197en_US
dc.identifier.urihttps://doi.org/10.1080/14767058.2018.1517314
dc.identifier.urihttps://hdl.handle.net/11616/98471
dc.identifier.volume33en_US
dc.identifier.wosWOS:000510748300017en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal of Maternal-Fetal & Neonatal Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHuman milken_US
dc.subjectlate onset hyponatremiaen_US
dc.subjectnewbornen_US
dc.subjectpretermen_US
dc.subjectsodiumen_US
dc.titleLate onset hyponatremia in preterm newborns: is the sodium content of human milk fortifier insufficient?en_US
dc.typeArticleen_US

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