Liver transplantation for hepatocellular carcinoma: Historical evolution of transplantation criteria

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dc.authoridAkbulut, Sami/0000-0002-6864-7711
dc.authoridince, volkan/0000-0002-0714-490X
dc.authorwosidAkbulut, Sami/L-9568-2014
dc.authorwosidince, volkan/M-7325-2017
dc.contributor.authorInce, Volkan
dc.contributor.authorSahin, Tevfik Tolga
dc.contributor.authorAkbulut, Sami
dc.contributor.authorYilmaz, Sezai
dc.date.accessioned2024-08-04T20:53:03Z
dc.date.available2024-08-04T20:53:03Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractLiver transplantation (LT) for hepatocellular carcinoma is still a hot topic, and the main factor that is associated with the success of treatment is to determine the patients who will benefit from LT. Milan criteria have been defined 25 years ago and still is being used for patient selection for LT. However, in living donor LT, the Milan criteria is being extended. Current criteria for patient selection do not only consider morphologic characteristics such as tumor size and number of tumor nodules but also biologic markers that show tumor aggressiveness is also being considered. In the present review article, we have summarized all the criteria and scoring systems regarding LT for hepatocellular carcinoma. All criteria have 5-year overall survival rates that were comparable to the Milan Criteria and ranged between 60%-85%. On the other hand, it was seen that the recurrence rates had increased as the Milan criteria were exceeded; the 5-year recurrence rates ranged between 4.9% to 39.9%. Treatment of hepatocellular carcinoma needs a multidisciplinary approach. Ideal selection criteria are yet to be discovered. The same is true for treatment modalities. The goal will be achieved by a harmonic interplay between basic science researchers and clinicians.en_US
dc.identifier.doi10.12998/wjcc.v10.i29.10413
dc.identifier.endpage10427en_US
dc.identifier.issn2307-8960
dc.identifier.issue29en_US
dc.identifier.pmid36312504en_US
dc.identifier.scopus2-s2.0-85139370730en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage10413en_US
dc.identifier.urihttps://doi.org/10.12998/wjcc.v10.i29.10413
dc.identifier.urihttps://hdl.handle.net/11616/100928
dc.identifier.volume10en_US
dc.identifier.wosWOS:000891904600003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBaishideng Publishing Group Incen_US
dc.relation.ispartofWorld Journal of Clinical Casesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectLiver transplantationen_US
dc.subjectHepatocellular carcinomaen_US
dc.subjectMilan criteriaen_US
dc.subjectExpanded Malatya criteriaen_US
dc.titleLiver transplantation for hepatocellular carcinoma: Historical evolution of transplantation criteriaen_US
dc.typeReview Articleen_US

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