Is contrast sensitivity a physiological marker in attention-deficit hyperactivity disorder?

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dc.authoridulucan ataş, pamuk betül/0000-0003-3751-3507
dc.authoridDönmez, Yunus Emre/0000-0002-7785-2805
dc.authorwosidDönmez, Yunus Emre/O-6102-2015
dc.authorwosidulucan ataş, pamuk betül/KDO-1236-2024
dc.authorwosidCEYLAN, OSMAN/AEB-2334-2022
dc.authorwosidCankaya, Cem/HTR-3803-2023
dc.authorwosidDönmez, Yunus Emre/AAV-9952-2021
dc.contributor.authorDonmez, Yunus Emre
dc.contributor.authorOzcan, Ozlem Ozel
dc.contributor.authorCankaya, Cem
dc.contributor.authorBerker, Merve
dc.contributor.authorAtas, Pamuk Betul Ulucan
dc.contributor.authorGunturkun, Pelin Nazli
dc.contributor.authorCeylan, Osman Melih
dc.date.accessioned2024-08-04T20:49:00Z
dc.date.available2024-08-04T20:49:00Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAttention-deficit hyperactivity disorder (ADHD) is one of the most common childhood-onset psychiatric disorders. Although the etiology is complex and has not yet been clarified, dopamine is thought to play a role in the etiology. Methylphenidate (MPH) is a psychostimulant drug used as first-line treatment for ADHD and it inhibits dopamine and norepinephrine reuptake transporters. Dopamine also has an effect on retina and contrast sensitivity. Despite evidence indicating the effects of dopamine on contrast sensitivity, the results of studies examining contrast sensitivity in ADHD patients are inconsistent. Also, no studies have been encountered examining the possible effect of MPH on contrast sensitivity. The hypotheses of this study are that children with ADHD who have not used MPH will have lower contrast sensitivity levels than the members of the control group, that contrast sensitivity levels increase after the use of MPH, and that contrast sensitivity is a potential physiological marker for ADHD. The study was conducted with 30 children with ADHD and 30 children without ADHD. Psychiatric evaluations of the participants were conducted with the Schedule for Affective Disorders and Schizophrenia for School Age Children-Present and Lifetime-Turkish version, Conner's Parent Rating Scale-Revised Short form and the Turgay DSM-IV-based Child and Adolescent Behavioral Disorders Screening and Rating Scale. Photopic contrast sensitivity was measured using the Functional Acuity Contrast Test (FACT). Results showed that FACT mean values of the control group were significantly higher than those of the ADHD group (pre-treatment) in all spatial frequencies. In four spatial frequencies (CPD 1.5, 3, 12 and 18), the FACT mean values of the control group were significantly higher than the ADHD group (during the OROS-MPH treatment). At all spatial frequencies, the mean values of the ADHD group during the OROS-MPH treatment were significantly higher than before the OROS-MPH treatment. In conclusion, the present study showed that contrast sensitivity is low in children with ADHD and increases significantly after OROS-MPH medication, but still did not reach the levels of the children without ADHD. Our findings suggest that contrast sensitivity may be a potential physiological marker in ADHD.en_US
dc.identifier.doi10.1016/j.mehy.2020.110326
dc.identifier.issn0306-9877
dc.identifier.issn1532-2777
dc.identifier.pmid33075582en_US
dc.identifier.scopus2-s2.0-85092742507en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.mehy.2020.110326
dc.identifier.urihttps://hdl.handle.net/11616/99591
dc.identifier.volume145en_US
dc.identifier.wosWOS:000597282700003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofMedical Hypothesesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectADHDen_US
dc.subjectContrast sensitivityen_US
dc.subjectMethylphenidateen_US
dc.subjectStimulanten_US
dc.titleIs contrast sensitivity a physiological marker in attention-deficit hyperactivity disorder?en_US
dc.typeArticleen_US

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