Venous leg symptoms, ecchymosis, and coldness in patients with peripheral varicose vein: A multicenter assessment and validation study (VEIN-VIOLET study)

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dc.authoridÖZYAŞAR, MEHMET/0000-0001-5227-1716
dc.authoridOzturk, Selcuk/0000-0002-3426-1212
dc.authoridErdil, Nevzat/0000-0002-8275-840X
dc.authorwosidIleri, Mehmet/A-6525-2018
dc.authorwosidÖZYAŞAR, MEHMET/AAW-4341-2021
dc.authorwosidOzturk, Selcuk/AFD-7629-2022
dc.authorwosidErdil, Nevzat/K-8079-2019
dc.contributor.authorYetkin, Ertan
dc.contributor.authorKutlu Karadag, Makbule
dc.contributor.authorIleri, Mehmet
dc.contributor.authorAtak, Ramazan
dc.contributor.authorErdil, Nevzat
dc.contributor.authorTekin, Gulacan
dc.contributor.authorOzyasar, Mehmet
dc.date.accessioned2024-08-04T20:49:08Z
dc.date.available2024-08-04T20:49:08Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives We aimed to evaluate peripheral varicose vein symptoms including ecchymosis and coldness by using the Venous Insufficiency Epidemiological and Economic Study-Quality of Life/Symptoms (VEINES-QoL/Sym) questionnaire. Methods A total of 1120 patients were enrolled to the analysis after the exclusion of 199 patients who did not match the inclusion criteria. Patients were asked to answer the VEINES-Sym questionnaire and questions about ecchymosis and coldness. Scores of ecchymosis and coldness were calculated similar to VEINES-Sym questionnaire. Classifications of peripheral varicose vein were made according to the clinical part of clinical, etiological, anatomical, and pathophysiological classification system and patients with grade 2 or higher were considered as positive for peripheral varicose vein. Results Frequency of symptoms present in the VEINES-Sym instrument, ecchymosis and coldness were significantly higher in patients with peripheral varicose vein. Mean score of each symptom was significantly lower in peripheral varicose vein patients including scores of ecchymosis and coldness. Logistic regression analysis revealed that presence of hemorrhoids and all symptoms in VEINES-Sym questionnaire except restless leg were significantly and independently associated with peripheral varicose vein. Besides, ecchymosis (odds ratio: 2.04, 95% confidence interval: 1.34-3.08, p = 0.008) but not coldness was significantly and independently associated with peripheral varicose vein. There was also significant correlation of VEINES-Sym score with ecchymosis (r = 0.43, p < 0.001) and coldness (r = 0.47, p < 0.001). Conclusions Venous leg symptoms present in VEINES-Sym questionnaire except restless legs, presence of hemorrhoids and ecchymosis are significantly and independently associated with peripheral varicose vein. Not only ecchymosis but also coldness has shown an independent association with total VEINES-Sym score.en_US
dc.description.sponsorshipVascular and Molecular Cardiology Societyen_US
dc.description.sponsorshipThe author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The study was funded by Vascular and Molecular Cardiology Society.en_US
dc.identifier.doi10.1177/1708538120980207
dc.identifier.endpage775en_US
dc.identifier.issn1708-5381
dc.identifier.issn1708-539X
dc.identifier.issue5en_US
dc.identifier.pmid33334264en_US
dc.identifier.scopus2-s2.0-85097736243en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage767en_US
dc.identifier.urihttps://doi.org/10.1177/1708538120980207
dc.identifier.urihttps://hdl.handle.net/11616/99675
dc.identifier.volume29en_US
dc.identifier.wosWOS:000627541800001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofVascularen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPeripheral varicose veinen_US
dc.subjectsymptomsen_US
dc.subjectleg diseasesen_US
dc.subjectecchymosisen_US
dc.titleVenous leg symptoms, ecchymosis, and coldness in patients with peripheral varicose vein: A multicenter assessment and validation study (VEIN-VIOLET study)en_US
dc.typeArticleen_US

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