Influence of Liver Transplantation on Neuropsychiatric Manifestations of Wilson Disease

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dc.authoridince, volkan/0000-0002-0714-490X
dc.authoridKaragul, Servet/0000-0003-1964-2516
dc.authoridYilmaz, Sezai/0000-0002-8044-0297
dc.authoridIsik, Burak/0000-0002-2395-3985
dc.authoridKayaalp, Cuneyt/0000-0003-4657-2998
dc.authoridKirmizi, Serdar/0000-0001-9385-1450
dc.authorwosidince, volkan/M-7325-2017
dc.authorwosidKayaalp, Cuneyt/AAH-1764-2021
dc.authorwosidKaragul, Servet/K-3020-2015
dc.authorwosidYilmaz, Sezai/ABI-2323-2020
dc.authorwosidIsik, Burak/A-6657-2018
dc.contributor.authorYagci, M. A.
dc.contributor.authorTardu, A.
dc.contributor.authorKaragul, S.
dc.contributor.authorErtugrul, I.
dc.contributor.authorInce, V.
dc.contributor.authorKirmizi, S.
dc.contributor.authorUnal, B.
dc.date.accessioned2024-08-04T20:40:18Z
dc.date.available2024-08-04T20:40:18Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives. This study sought to evaluate the effect of liver transplantation on the neuropsychological manifestations of Wilson disease. Materials and Methods. Nine of 42 Wilson disease patients had neuropsychological symptoms before liver transplantation. They were 7 male and 2 female subjects with a median age of 19 years (range 10 to 25). They were analyzed for their preoperative and postoperative hepatic, neurological, and psychological scores described by the Unified Wilson Disease Rating Scale after a mean 36.6 months of follow-up. Results. Preoperative mean Model for End-Stage Liver Disease and Child-Pugh scores were 18.3 (range 15 to 26) and 8.9 (range 6 to 12), respectively. One patient had acute postoperative ischemic stroke unrelated to Wilson disease and was excluded from the statistical analysis. Preoperative and postoperative hepatic, neurological, and psychological scores of the remaining 8 patients were 7.4 +/- 2.3 vs 2.4 +/- 1.3 (P = .0005), 17.7 +/- 11.7 vs 12.7 +/- 12.5 (P = .055), and 9.0 +/- 1.7 vs 7.0 +/- 2.1 (P = .033). Conclusions. Liver transplantation for Wilson disease can provide some improvement of the neuropsychological symptoms in addition to the hepatic recovery.en_US
dc.identifier.doi10.1016/j.transproceed.2015.04.017
dc.identifier.endpage1473en_US
dc.identifier.issn0041-1345
dc.identifier.issn1873-2623
dc.identifier.issue5en_US
dc.identifier.pmid26093745en_US
dc.identifier.scopus2-s2.0-84931476779en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1469en_US
dc.identifier.urihttps://doi.org/10.1016/j.transproceed.2015.04.017
dc.identifier.urihttps://hdl.handle.net/11616/96840
dc.identifier.volume47en_US
dc.identifier.wosWOS:000357066800057en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofTransplantation Proceedingsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectExperienceen_US
dc.titleInfluence of Liver Transplantation on Neuropsychiatric Manifestations of Wilson Diseaseen_US
dc.typeArticleen_US

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