Protective effects of naringin on valproic acid-induced hepatotoxicity in rats

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dc.authoridGunata, Mehmet/0000-0001-6905-4259
dc.authoridYildiz, Azibe/0000-0001-5686-7867
dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridAteş, Burhan/0000-0001-6080-229X
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridÇOLAK, CEMİL/0000-0001-5406-098X
dc.authorwosidGunata, Mehmet/AAW-2738-2021
dc.authorwosidYildiz, Azibe/ABI-7998-2020
dc.authorwosidVardı, Nigar/C-9549-2018
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidAteş, Burhan/AAA-3730-2021
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidÇOLAK, CEMİL/ABI-3261-2020
dc.contributor.authorKoroglu, Omer Faruk
dc.contributor.authorGunata, Mehmet
dc.contributor.authorVardi, Nigar
dc.contributor.authorYildiz, Azibe
dc.contributor.authorAtes, Burhan
dc.contributor.authorColak, Cemil
dc.contributor.authorTanriverdi, Lokman Hekim
dc.date.accessioned2024-08-04T20:49:24Z
dc.date.available2024-08-04T20:49:24Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractValproic acid (VPA) is mainly prescribed to treat epilepsy. VPA has been reported to be associated with many adverse effects, including hepatotoxicity. Naringin (NRG) is a natural, therapeutically active flavanone glycoside with anti-inflammatory, anti-apoptotic, and antioxidant. The current study was therefore designed to investigate the protective effect of NRG against the VPA-induced experimental hepatotoxicity model. For this purpose, 24 Wistar albino rats were randomly divided into three groups as control (Vehicle), VPA (500 mg/kg), and NRG + VPA (100 mg/kg NRG + 500 mg/kg VPA) groups. The agents were administered via oral gavage for 14 days. Blood and liver tissue samples were taken on the end of the experiment. Biochemical analyzes were performed on the blood and liver samples. Also, malondialdehyde (MDA), superoxide dismutase (SOD) enzyme, glutathione (GSH) content, catalase (CAT) enzyme levels were examined in the liver tissue samples. Histopathological changes (hydropic degeneration and congestion) in the VPA group were increased significantly when compared to the control group (p < 0.05). We also found a decrease in enzymes of serum liver function in the VPA group. However, NRG has been shown not to prevent histopathological changes in the VPA group. According to our results with this experiment protocol, NRG could not exert sufficient protection against VPA-induced hepatotoxicity.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey [1919B011900530]en_US
dc.description.sponsorshipThis work was supported by the [2209-A research grant from the Scientific and Technological Research Council of Turkey] under Grant [number 1919B011900530]en_US
dc.identifier.doi10.1016/j.tice.2021.101526
dc.identifier.issn0040-8166
dc.identifier.pmid33756270en_US
dc.identifier.scopus2-s2.0-85102765718en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.tice.2021.101526
dc.identifier.urihttps://hdl.handle.net/11616/99830
dc.identifier.volume72en_US
dc.identifier.wosWOS:000693937400002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherChurchill Livingstoneen_US
dc.relation.ispartofTissue & Cellen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntioxidantsen_US
dc.subjectHepatotoxicityen_US
dc.subjectNaringinen_US
dc.subjectOxidative stressen_US
dc.subjectValproic aciden_US
dc.subjectRaten_US
dc.titleProtective effects of naringin on valproic acid-induced hepatotoxicity in ratsen_US
dc.typeArticleen_US

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