The analgesic effect of apelin-13 and its mechanism of action within the nitric oxide and serotonin pathways

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dc.authoridTurtay, Muhammet Gokhan/0000-0002-1728-8237
dc.authoridÇOLAK, CEMİL/0000-0001-5406-098X
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authorwosidTurtay, Muhammet Gokhan/ABG-7401-2020
dc.authorwosidÇOLAK, CEMİL/ABI-3261-2020
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.contributor.authorTurtay, M. G.
dc.contributor.authorKarabas, M.
dc.contributor.authorParlakpinar, H.
dc.contributor.authorColak, C.
dc.contributor.authorSagir, M.
dc.date.accessioned2024-08-04T20:41:50Z
dc.date.available2024-08-04T20:41:50Z
dc.date.issued2015
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Apelin has various effects on a lot of systems such as central nervous system and cardiovascular system. This study investigated the possible analgesic effects of apelin-13 using the hot-plate and the tail-flick thermal analgesia tests in rats. We also evaluated the mechanism underlying the analgesic effects of apelin-13 by pretreating with Nw-nitro-L-arginine methyl ester (L-NAME) or ondansetron. Material & Methods: Forty male rats were used. The rats were randomly assigned to five groups according to the treatment received: Group I: Control; Group II: Morphine; Group III: Apelin-13; Group IV: Apelin-13+L-NAME; Group V: Apelin-13+ Ondansetron. Acute thermal pain was modeled using the hot-plate and the tail-flick tests. Results: During the hot-plate test, i.p. Morphine and apelin-13 administered at zero-and 30 min produced significantly greater analgesic effects compared to the control. When the nitric oxide pathway was inhibited by administration of L-NAME with apelin-13, the analgesic effect continued. When apelin-13 and ondansetron were co-administered, the analgesic effect of apelin-13 disappeared at zero-and 30 min. During the tail-flick test, at 30 min, significantly higher levels of analgesia were observed in both the morphine and apelin group (which did not differ from each other) compared to the control group. L-NAME co-administered with apelin-13 did not affect the degree of analgesia, but apelin-13 co-administered with ondansetron was associated with a greater reduction in analgesia compared to the other groups. Conclusion: Our results demonstrate that apelin-13 exerts an analgesic effect; co-administration of apelin-13 and ondansetron inhibits antinociception, an effect apparently mediated by five-hydroxytryptamine-three (5-HT3) receptors.en_US
dc.description.sponsorshipTUBITAK (The Scientific and Technological Research Council of Turkey) [2209]en_US
dc.description.sponsorshipWe acknowledge the support of TUBITAK (The Scientific and Technological Research Council of Turkey) under grant 2209, Student Project.en_US
dc.identifier.endpage323en_US
dc.identifier.issn1108-4189
dc.identifier.issue4en_US
dc.identifier.pmid27688696en_US
dc.identifier.scopus2-s2.0-84975127373en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage319en_US
dc.identifier.urihttps://hdl.handle.net/11616/97380
dc.identifier.volume19en_US
dc.identifier.wosWOS:000378291200007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLithographiaen_US
dc.relation.ispartofHippokratiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApelin-13en_US
dc.subjectanalgesicen_US
dc.subjectraten_US
dc.subjectnitric oxideen_US
dc.subjectserotoninen_US
dc.titleThe analgesic effect of apelin-13 and its mechanism of action within the nitric oxide and serotonin pathwaysen_US
dc.typeArticleen_US

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