4-Vinylbenzyl and 2-morpholinoethyl substituted ruthenium (II) complexes: Design, synthesis, and biological evaluation

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dc.authoridAktaş, Aydın/0000-0001-8496-6782
dc.authoridAteş, Burhan/0000-0001-6080-229X
dc.authoridKeleştemur, Ünzile/0000-0003-4531-6378
dc.authoridGürses, Canbolat/0000-0002-4085-0224
dc.authoridYuksel, Sengul/0000-0002-7190-431X
dc.authorwosidAktaş, Aydın/J-6194-2019
dc.authorwosidBarut Celepci, Duygu/M-6189-2017
dc.authorwosidAteş, Burhan/AAA-3730-2021
dc.authorwosidGök, Yetkin/AAA-5669-2021
dc.authorwosidKeleştemur, Ünzile/A-4190-2018
dc.authorwosidGürses, Canbolat/AAA-6825-2019
dc.authorwosidYuksel, Sengul/ABI-2182-2020
dc.contributor.authorSari, Yakup
dc.contributor.authorGurses, Canbolat
dc.contributor.authorCelepci, Duygu Barut
dc.contributor.authorKelestemur, Unzile
dc.contributor.authorAktas, Aydin
dc.contributor.authorYuksel, Sengul
dc.contributor.authorAtes, Burhan
dc.date.accessioned2024-08-04T20:46:56Z
dc.date.available2024-08-04T20:46:56Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractRecently, the medical applications of organoruthenium complexes have attention attracted to organometallic chemists and biochemists. In this study, 4-vinylbenzyl and 2-morpholinoethyl substituted (NHC) Ru(II)(eta(6)-p-cymene) complexes were synthesized and in vitro DNA binding, cell cytotoxicity (anticancer activity) and genotoxicity properties were determined in order to understand the biological activities. These complexes have been prepared from the 4-vinylbenzyl and 2-morpholinoethyl substituted Ag(I) NHC complexes via transmetallation method. The characterization of the new (NHC)Ru(II)(eta(6)-p-cymene) complexes was performed by using H-1 NMR, C-13 NMR, FTIR spectroscopy and elemental analysis techniques. Also, molecular structure of complex 1b was obtained with single-crystal X-ray diffraction method. IC50 value of 1b against MCF-7 cell line was determined as 3.61 mu M and for 1b, an oxidation effect was observed in the concentrations higher than 50 mu g/mL. Comet assay unlike sister chromatid exchange (SCE) analysis data showed correlated results with cytotoxicity as well as DNA binding properties of the complexes. (C) 2019 Elsevier B.V. All rights reserved.en_US
dc.description.sponsorshipInonu University Research Fund in Turkey (IUBAP FOA) [2018-1342]; University Research Grant [2010.KB.FEN.13]en_US
dc.description.sponsorshipThis work was financially supported by Inonu University Research Fund in Turkey (IUBAP FOA-2018-1342). The authors acknowledge Inonu University Scientific and Technology Center for the elemental analyses of the compounds, and Dokuz Eylul University for the use of the Rigaku Oxford Xcalibur Eos Diffractometer (purchased under University Research Grant No: 2010.KB.FEN.13).en_US
dc.identifier.doi10.1016/j.molstruc.2019.127355
dc.identifier.issn0022-2860
dc.identifier.issn1872-8014
dc.identifier.scopus2-s2.0-85075385445en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.molstruc.2019.127355
dc.identifier.urihttps://hdl.handle.net/11616/99063
dc.identifier.volume1202en_US
dc.identifier.wosWOS:000501486700003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofJournal of Molecular Structureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectN-Heterocyclic carbenesen_US
dc.subjectRuthenium complexesen_US
dc.subjectX-ray diffractionen_US
dc.subjectCrystal structureen_US
dc.subjectDNA bindingen_US
dc.subjectGenotoxicityen_US
dc.title4-Vinylbenzyl and 2-morpholinoethyl substituted ruthenium (II) complexes: Design, synthesis, and biological evaluationen_US
dc.typeArticleen_US

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