Synthesis and Radical Scavenging Properties of Selenophenyl Benzamide Anologs

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dc.authoridAteş, Burhan/0000-0001-6080-229X
dc.authoridKARAASLAN, MERVE GOKSIN/0000-0003-2645-808X
dc.authorwosidAteş, Burhan/AAA-3730-2021
dc.contributor.authorDoganay, Kadir
dc.contributor.authorKaraaslan, Merve Goksin
dc.contributor.authorAtes, Burhan
dc.contributor.authorAltundas, Aliye
dc.date.accessioned2024-08-04T20:41:50Z
dc.date.available2024-08-04T20:41:50Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractFree radicals that result from different kinds of oxidative stress have been concerned in a variety of human disorders, from cardiac ischemia to those affecting the central nervous system. So, there is an increasing interest in the development of antioxidant molecules that can protect cells against free radical damages. Sets of tetrasubstituted selenophene amides 4a-e were synthesized by reaction of 2-amino-5,6,7,8-tetrahydro-4H-cyclohepta[b] selenophen-3-carbonitrile (2) with benzoyl chloride derivatives and the structures of the amide derivatives were characterized by MS, H-1-NMR, C-13-NMR and IR spectra. The synthesized compounds (4a-e) were evaluated in terms of in vitro. The antioxidant properties were determined by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging properties and IC50 values of the compounds were in the range from 3.794 to 5.644 mg/mL. Compounds 4c and 4e showed predominant radical scavenging activity among the synthesized analogues.en_US
dc.description.sponsorshipGazi University; Inonu University Research fund [IUBAP-2011/40]en_US
dc.description.sponsorshipThe authors would like to thanks Gazi University and Inonu University Research fund (Project number: IUBAP-2011/40) for their financial supports.en_US
dc.identifier.endpage321en_US
dc.identifier.issn2147-1762
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-84975127039en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage317en_US
dc.identifier.urihttps://hdl.handle.net/11616/97378
dc.identifier.volume29en_US
dc.identifier.wosWOS:000378738800012en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherGazi Univen_US
dc.relation.ispartofGazi University Journal of Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSelenopheneen_US
dc.subjectSelenopheneyl benzamideen_US
dc.subjectAntioxidant activityen_US
dc.titleSynthesis and Radical Scavenging Properties of Selenophenyl Benzamide Anologsen_US
dc.typeArticleen_US

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