Predictors of left ventricular thrombus formation in patients with dilated cardiomyopathy: role of activated protein C resistance

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dc.authoridmemişoğlu, funda/0000-0003-3905-1182
dc.authorwosidmemişoğlu, funda/AAA-4392-2021
dc.contributor.authorErbay, AR
dc.contributor.authorTurhan, H
dc.contributor.authorSenen, K
dc.contributor.authorYetkin, F
dc.contributor.authorAyaz, S
dc.contributor.authorKara, F
dc.contributor.authorBuyukasik, NS
dc.date.accessioned2024-08-04T20:14:43Z
dc.date.available2024-08-04T20:14:43Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObjectives The aim of this study was to investigate the association between left ventricular thrombus formation and natural anticoagulant systems including the protein C, protein S and antithrombin in patients with dilated cardiomyopathy. Materials and methods Sixty patients with dilated cardiomyopathy who met the inclusion criteria were included in the study. Patients were divided into two groups: group I consisted of 22 patients with left ventricular thrombus and group II consisted of 38 patients without left ventricular thrombus. Our main inclusion criteria were ejection fraction less than or equal to 35% and left ventricular end-diastolic diameter greater than or equal to 6.0 cm. These two groups were compared for clinical and hematologic parameters (activated protein C resistance, protein S and antithrombin). Results There were no statistically significant differences between patients with or without left ventricular thrombi with respect to left ventricular end-diastolic and end-systolic dimensions, ejection fraction, fractional shortening and left atrial diameter. There were no statistically significant differences between patients with and without left ventricular thrombus with respect to platelet count (252 +/- 64/mm(3) x 10(3) compared with 260 +/- 74/mm(3) x 10(3) respectively, P=0.68), prothrombin time (12.94 +/- 1.9s compared with 12.86 +/- 1.3 s respectively, P=0.82), activated partial thromboplastin time (32 +/- 5 compared with 30 +/- 4 s respectively, P= 0.32) and fibrinogen levels (36 +/- 9 mg/dl compared with 34 +/- 8 mg/dl respectively, P=0.41). None of the patients had protein S and antithrombin deficiency. Activated protein C resistance was found in 12 patients (12 out of 22, 54%) in group I and four patients (four out of 38, 9.5%) in group II (P < 0.01). It was also shown to be an independent predictor of left ventricular thrombus (P < 0.05). Conclusion Activated protein C resistance is found to be an independent predictor of left ventricular thrombus in patients with dilated cardiomyopathy who have ejection fractions less then 35% and left ventricular end-diastolic dimensions > 6.0 cm.en_US
dc.identifier.doi10.1097/00019501-200403000-00006
dc.identifier.endpage110en_US
dc.identifier.issn0954-6928
dc.identifier.issn1473-5830
dc.identifier.issue2en_US
dc.identifier.pmid15024298en_US
dc.identifier.scopus2-s2.0-1842505385en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage107en_US
dc.identifier.urihttps://doi.org/10.1097/00019501-200403000-00006
dc.identifier.urihttps://hdl.handle.net/11616/93913
dc.identifier.volume15en_US
dc.identifier.wosWOS:000220654700006en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofCoronary Artery Diseaseen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectactivated protein C resistanceen_US
dc.subjectdilated cardiomyopathyen_US
dc.subjectleft ventricular thrombusen_US
dc.titlePredictors of left ventricular thrombus formation in patients with dilated cardiomyopathy: role of activated protein C resistanceen_US
dc.typeArticleen_US

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