Vascular endothelial function in patients with slow coronary flow

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dc.authorid7768en_US
dc.contributor.authorSığırcı, Ahmet
dc.contributor.authorBarutçu, İrfan
dc.contributor.authorTopal, Ergün
dc.contributor.authorSezgin, Nurzen
dc.contributor.authorÖzdemir,Ramazan
dc.contributor.authorYetkin, Ertan
dc.contributor.authorTandoğan, İzzet
dc.contributor.authorKoşar, Feridun
dc.contributor.authorErmiş, Necip
dc.contributor.authorYoloğlu, Saim
dc.contributor.authorBarskaner, Emrah
dc.contributor.authorÇehreli, Şengül
dc.contributor.authorSezgin, Alpay Turan
dc.date.accessioned2017-06-23T13:53:26Z
dc.date.available2017-06-23T13:53:26Z
dc.date.issued2003
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground: Slow coronary flow (SCF) in a normal coronary angiogram is a well-recognized clinical entity, but its etiopathogenesis remains unclear. Design: The aim of the study was to determine endothelial function in patients with SCF using a flow-mediated dilatation (FMD) technique in the brachial artery. Methods: Coronary flow was quantified using the corrected thrombosis in myocardial infarction (TIMI) frame count (CTFC) method. Endothelial function was studied in 27 patients with SCF (23 men, four women, mean age 47.6±8.7 years) and in 30 people with normal coronary flow (NCF) (22 men and eight women, mean age 47.5±7.4 years). Results: The flow-mediated diameter increase in the SCF group was significantly smaller than that in the NCF group (3.48±0.10% compared with 9.11±0.10%, P < 0.001). The percentage of nitroglycerine (NTG)-induced dilatation was not significantly different between patients with SCF and people with NCF (16.8±1.1% compared with 17.1±1.1%, P = 0.87). Simple regression analysis showed that mean CTFC (CTFCm) was strongly and inversely related to the percentage of FMD (r = –0.29, P < 0.01) in all participants. When the patients with SCF were excluded, CTFCm was still inversely related to the percentage of FMD (r = –0.36, P < 0.05). CTFCm was also inversely related to NTG-induced dilatation in the 57 participants (r = –0.23, P < 0.05). Multiple regression analysis showed that CTFCm was inversely related to the percentage of FMD only (r = –0.37, P < 0.05). Conclusions: These findings suggest that endothelial function is impaired in people with SCF and that CTFC correlates well with endothelial dysfunction.en_US
dc.identifier.citationSezgin, A. T. Sığırcı, A. Barutçu, İ. Topal, E. Sezgin, N. Özdemir, R. Yetkin, E. Tandoğan, İ. Koşar, F. Ermiş, N. Yoloğlu, S. Barskaner, E. Çehreli, Ş. (2003). Vascular endothelial function in patients with slow coronary flow. Coron Artery Dis, (14), 155–161.en_US
dc.identifier.endpage161en_US
dc.identifier.startpage155en_US
dc.identifier.urihttp://journals.lww.com/coronary-artery/Abstract/2003/04000/Vascular_endothelial_function_in_patients_with.8.aspx
dc.identifier.urihttps://hdl.handle.net/11616/7168
dc.identifier.volume14en_US
dc.language.isoenen_US
dc.publisherCoron Artery Disen_US
dc.relation.ispartofCoron Artery Disen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.titleVascular endothelial function in patients with slow coronary flowen_US
dc.typeArticleen_US

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