The Hemodynamic Effects of Dexmedetomidine and Esmolol in Electroconvulsive Therapy A Retrospective Comparison

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dc.authoridaydogan, mustafa said/0000-0002-7106-1156
dc.authoridYücel, Aytaç/0000-0003-0270-8339
dc.authoridcolak, yusuf ziya/0000-0002-8729-8705
dc.authoridDurmus, Mahmut/0000-0001-9594-9064
dc.authoridbegeç, zekine/0000-0002-9506-1871
dc.authorwosidaydogan, mustafa said/AAA-2828-2021
dc.authorwosidYücel, Aytaç/ABI-6137-2020
dc.authorwosidcolak, yusuf ziya/ABH-3032-2020
dc.authorwosidDurmuş, Mahmut/AAG-3377-2019
dc.authorwosidDurmus, Mahmut/ABH-3006-2020
dc.authorwosidbegeç, zekine/ABI-5491-2020
dc.contributor.authorAydogan, Mustafa Said
dc.contributor.authorYucel, Aytac
dc.contributor.authorBegec, Zekine
dc.contributor.authorColak, Yusuf Ziya
dc.contributor.authorDurmus, Mahmut
dc.date.accessioned2024-08-04T20:37:57Z
dc.date.available2024-08-04T20:37:57Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractAim: Acute hemodynamic responses, including transient hypertension and tachycardia, to electroconvulsive therapy (ECT) predispose vulnerable patients to significant cardiovascular complications. Many drugs have been used in an attempt to attenuate these responses. To date, no comparative study of the acute hemodynamic effects of dexmedetomidine and esmolol in ECT has been published. Hence, this retrospective study aimed to compare the effects of dexmedetomidine and esmolol on acute hemodynamic responses in patients undergoing ECT. Materials and Methods: The anesthesia records for 66 patients who underwent a total of 198 ECT treatments performed between July 2009 and January 2010 were analyzed retrospectively. For each case, 1 seizure with 1-mg/kg propofol as control (group C), 1 seizure with 1-mu g/kg dexmedetomidine combined with propofol (group D; total volume, 30 mL for 10 minutes), and 1 seizure with 1-mg/kg esmolol combined with propofol were compared (group E; total volume, 30 mL for 10 minutes). Anesthesia was induced with 1-mg/kg propofol, and then intravenous succinylcholine, 0.5-mg/kg, was administered. Heart rates and systolic and mean blood pressures were recorded at baseline (T-0) and 1, 3, and 10 minutes after the seizure (T-1, T-2, and T-3, respectively). The electroencephalographic (EEG) tracing motor seizure duration, and recovery times (spontaneous breathing, eye opening, and obeying commands) were recorded. Results: The baseline hemodynamic measurements were similar between the groups. Heart rates at T-1, T-2, and T-3 were lower in group D than those in groups E and C (P < 0.05). Systolic blood pressures at T-1, T-2, and T-3 were lower in group D than those in groups C (P < 0.05). In addition, systolic blood pressure at T-3 was lower in group D than that in group E (P < 0.05). The mean blood pressure at T3 was significantly lower in group D than those in groups E and C (P <0.05). The electroencephalographic tracing, motor seizure durations, and recovery times were similar between the groups. Conclusion: Dexmedetomidine administration before anesthesia induction reduced the acute hemodynamic response compared with esmolol administration in the early period of ECT. Therefore, dexmedetomidine may be effective in preventing acute hemodynamic responses to ECT.en_US
dc.identifier.doi10.1097/YCT.0b013e3182972bec
dc.identifier.endpage311en_US
dc.identifier.issn1095-0680
dc.identifier.issn1533-4112
dc.identifier.issue4en_US
dc.identifier.pmid23774056en_US
dc.identifier.scopus2-s2.0-84889088926en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage308en_US
dc.identifier.urihttps://doi.org/10.1097/YCT.0b013e3182972bec
dc.identifier.urihttps://hdl.handle.net/11616/96291
dc.identifier.volume29en_US
dc.identifier.wosWOS:000330362600019en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofJournal of Ecten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectelectroconvulsive therapyen_US
dc.subjecthemodynamic responseen_US
dc.subjectdexmedetomidineen_US
dc.subjectesmololen_US
dc.titleThe Hemodynamic Effects of Dexmedetomidine and Esmolol in Electroconvulsive Therapy A Retrospective Comparisonen_US
dc.typeArticleen_US

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