Endothelial nitric oxide synthase expression in leiomyoma and parental myometrium

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dc.contributor.authorGokdeniz, R
dc.contributor.authorMizrak, B
dc.contributor.authorOzen, S
dc.contributor.authorBazoglu, N
dc.date.accessioned2024-08-04T20:12:08Z
dc.date.available2024-08-04T20:12:08Z
dc.date.issued2000
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of this study was to determine the expression of endothelial nitric oxide synthase (eNOS) in leiomyomatous tissue as a possible mediator of the growth process. Nine patients had myoma enucleation during the follicular phase. The myomata and adjacent myometrial tissues were fixed in formol until study. Immunohistochemical localization of leiomyomatous and myometrial tissue eNOS expression was performed using specific monoclonal antibodies to eNOS. Statistical comparisons were made using the Mann-Whitney Wilcoxon rank-sum test for the expression of eNOS. The test was considered significant when p values were <0.05. Immunostaining for eNOS was seen in the cytoplasm of myometrial endothelial and smooth muscle cells in both tissue sections. eNOS expression was significantly higher in the smooth muscle cells of leiomyomata, compared to parental myometrium (p < 0.0005). The expression of eNOS in vascular endothelial cells was not different in the leiomyoma and myometrium (p > 0.05). To our knowledge, this is the first study to document marked expression of eNOS in leiomyomatous tissue, compared to parental myometrium. We also conclude that the mechanism(s) of the growth-promoting effect of estrogen on leiomyomata is mediated by more synthesis of NO. Copyright (C) 2000 S. Karger AG, Basel.en_US
dc.identifier.doi10.1159/000010231
dc.identifier.endpage136en_US
dc.identifier.issn0378-7346
dc.identifier.issue2en_US
dc.identifier.pmid10671823en_US
dc.identifier.scopus2-s2.0-0033961663en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage132en_US
dc.identifier.urihttps://doi.org/10.1159/000010231
dc.identifier.urihttps://hdl.handle.net/11616/93240
dc.identifier.volume49en_US
dc.identifier.wosWOS:000085575200015en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofGynecologic and Obstetric Investigationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectendothelial nitric oxide synthaseen_US
dc.subjectleiomyomaen_US
dc.subjectparental myometriumen_US
dc.titleEndothelial nitric oxide synthase expression in leiomyoma and parental myometriumen_US
dc.typeArticleen_US

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