Evaluation of the effects of resveratrol and bevacizumab on experimental corneal alkali burn

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dc.authoridBozgul, Pembegul/0000-0002-9427-3610
dc.authoridcankaya, cem/0000-0002-7716-0438
dc.authorwosidBozgul, Pembegul/AAQ-4951-2020
dc.authorwosidCankaya, Cem/HTR-3803-2023
dc.authorwosidcankaya, cem/ABH-6458-2020
dc.contributor.authorDoganay, Selim
dc.contributor.authorFirat, Penpe Gul
dc.contributor.authorCankaya, Cem
dc.contributor.authorKirimlioglu, Hale
dc.date.accessioned2024-08-04T20:37:25Z
dc.date.available2024-08-04T20:37:25Z
dc.date.issued2013
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose: To evaluate the effects of resveratrol and bevacizumab on experimental corneal neovascularization. Method: A corneal alkali burn was performed in 62 eyes of 31 male white Vienna rabbits. Resveratrol (group 1), dimethyl sulfoxide (group 2), bevacizumab (group 3) and 0.9% NaCl (group 4) were administered to both eyes of the rabbits by subconjunctival injection for 7 days. Corneal photos were taken at 15 days after alkali injury. Inflammatory index scores and neovascularization areas were calculated. Results: In bevacizumab group both inflammatory index scores and the calculation of the corneal neovascularization area was significantly less than the groups. Conclusion: The subconjunctival administration of bevacizumab inhibits corneal neovascularization effectively in the rabbit corneal alkali burn model. No effect of resveratrol to the corneal neovascularization on experimental model of the corneal alkali burn was seen at the doses of usage. (C) 2012 Elsevier Ltd and ISBI. All rights reserved.en_US
dc.identifier.doi10.1016/j.burns.2012.07.018
dc.identifier.endpage330en_US
dc.identifier.issn0305-4179
dc.identifier.issn1879-1409
dc.identifier.issue2en_US
dc.identifier.pmid22922008en_US
dc.identifier.scopus2-s2.0-84873730190en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage326en_US
dc.identifier.urihttps://doi.org/10.1016/j.burns.2012.07.018
dc.identifier.urihttps://hdl.handle.net/11616/95952
dc.identifier.volume39en_US
dc.identifier.wosWOS:000316520400018en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofBurnsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBevacizumaben_US
dc.subjectCorneal neovascularizationen_US
dc.subjectResveratrolen_US
dc.titleEvaluation of the effects of resveratrol and bevacizumab on experimental corneal alkali burnen_US
dc.typeArticleen_US

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