2-Morpholinoethyl-substituted N-heterocyclic carbene (NHC) precursors and their silver(I)NHC complexes: synthesis, crystal structure and in vitro anticancer properties

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dc.authoridAktaş, Aydın/0000-0001-8496-6782
dc.authoridAygün, Muhittin/0000-0001-9670-9062
dc.authoridKeleştemur, Ünzile/0000-0003-4531-6378
dc.authoridBALCIOGLU, Sevgi/0000-0003-0724-4772
dc.authoridAteş, Burhan/0000-0001-6080-229X
dc.authoridBALCIOGLU, Sevgi/0000-0003-0724-4772
dc.authorwosidAktaş, Aydın/J-6194-2019
dc.authorwosidGök, Yetkin/AAA-5669-2021
dc.authorwosidAygün, Muhittin/E-9590-2011
dc.authorwosidKeleştemur, Ünzile/A-4190-2018
dc.authorwosidBALCIOGLU, Sevgi/O-3576-2015
dc.authorwosidAteş, Burhan/AAA-3730-2021
dc.authorwosidBALCIOGLU, Sevgi/W-5874-2018
dc.contributor.authorAktas, Aydin
dc.contributor.authorKelestemur, Unzile
dc.contributor.authorGok, Yetkin
dc.contributor.authorBalcioglu, Sevgi
dc.contributor.authorAtes, Burhan
dc.contributor.authorAygun, Muhittin
dc.date.accessioned2024-08-04T20:44:14Z
dc.date.available2024-08-04T20:44:14Z
dc.date.issued2018
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn this study, a series of unsymmetrically 2-morpholinoethyl-substituted benzimidazolium salts and their Ag(I)NHC complexes were synthesized. The 1,3-dialkylbenzimidazolium salts (1a-d) were synthesized in dimethylformamide at 80 A degrees C temperature from the N-(2-morpholinoethyl)benzimidazole and alkyl halides. The Ag(I)NHC complexes (2a-d) were synthesized in dichloromethane at room temperature from the benzimidazolium salts and Ag2O. All compounds were characterized by spectroscopic techniques (NMR and FT-IR) and elemental analyses. Also, the salt 1c and complex 2c were characterized by single-crystal X-ray crystallography. Anticancer activities of 2-morpholinoethyl-substituted benzimidazolium salts and Ag(I)NHC complexes were investigated against the MCF-7 breast cancer cell line, and the IC30 and IC50 values of these compounds were found to be in the range of 241-490 and 6-14 A mu M, respectively.en_US
dc.description.sponsorshipDokuz Eylul University [2010.KB.FEN.13]en_US
dc.description.sponsorshipThe authors acknowledge Dokuz Eylul University for the use of the Agilent Xcalibur Eos diffractometer (purchased under University Research Grant No: 2010.KB.FEN.13).en_US
dc.identifier.doi10.1007/s13738-017-1216-8
dc.identifier.endpage139en_US
dc.identifier.issn1735-207X
dc.identifier.issn1735-2428
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85039988907en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage131en_US
dc.identifier.urihttps://doi.org/10.1007/s13738-017-1216-8
dc.identifier.urihttps://hdl.handle.net/11616/98102
dc.identifier.volume15en_US
dc.identifier.wosWOS:000419172500015en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of The Iranian Chemical Societyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectN-Heterocyclic carbenesen_US
dc.subjectBenzimidazolium salten_US
dc.subjectSilver(I)NHC complexesen_US
dc.subjectMedical inorganic chemistryen_US
dc.subjectAnticancer agentsen_US
dc.subjectX-ray diffractionen_US
dc.title2-Morpholinoethyl-substituted N-heterocyclic carbene (NHC) precursors and their silver(I)NHC complexes: synthesis, crystal structure and in vitro anticancer propertiesen_US
dc.typeArticleen_US

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