Serum nitrite and nitrate levels in epileptic children using valproic acid or carbamazepine

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dc.authoriddurmaz, yasar/0000-0002-4437-0068
dc.authoridYakıncı, Mehmet Cengiz/0000-0001-5930-4269
dc.authoridDURMAZ, YASAR/0000-0002-4437-0068
dc.authorwosiddurmaz, yasar/AAR-4655-2020
dc.authorwosidYakıncı, Mehmet Cengiz/ABI-7519-2020
dc.authorwosidDURMAZ, YASAR/JVO-4824-2024
dc.contributor.authorKarabiber, H
dc.contributor.authorYakinci, C
dc.contributor.authorDurmaz, Y
dc.contributor.authorTemel, I
dc.contributor.authorMehmet, N
dc.date.accessioned2024-08-04T20:12:10Z
dc.date.available2024-08-04T20:12:10Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIn experimental epilepsy studies, nitric oxide was found to act as both proconvulsant and anticonvulsant. The objective. of this study was to investigate the effects of valproic acid and carbamazepine on serum levels of nitrite and nitrate, which are the metabolites of nitric oxide. To achieve this goal, serum nitrite and nitrate levels were determined in active epileptic 34 children using valproic acid and 23 children using carbamazepine and in non-active epileptic 38 children (control group) not using any antiepileptic drug. In the valproic acid group serum nitrite and nitrate levels were 2.66 +/- 2.11 mumol/l and 69.35 +/- 23.20 mumol/l, 1.89 +/- 1.01 mumol/l and 49.39 +/- 10.61 mumol/l in the carbamazepine group, and 1.22 +/- 0.55 mumol/l, 29.53 +/- 10.05 mumol in the control group, respectively. Nitrite and nitrate levels were significantly high in both valproic acid and carbamazepine groups compared to the control group (P < 0.01). When valproic acid and carbamazepine groups were compared to each other, level of nitrate was found statistically higher in the valproic acid group in relation to the carbamazepine group (P < 0.01), however, there was no statistically significant difference in the levels of nitrite (P > 0.05). No relation could be found between serum drug levels and nitrite and nitrate levels. According to these results, it can be suggested that valproic acid and carbamazepine might have antiepileptic effects through nitric oxide. (C) 2003 Elsevier B.V. All fights reserved.en_US
dc.identifier.doi10.1016/S0387-7604(03)00076-7
dc.identifier.endpage18en_US
dc.identifier.issn0387-7604
dc.identifier.issue1en_US
dc.identifier.pmid14729409en_US
dc.identifier.scopus2-s2.0-0034516974en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage15en_US
dc.identifier.urihttps://doi.org/10.1016/S0387-7604(03)00076-7
dc.identifier.urihttps://hdl.handle.net/11616/93269
dc.identifier.volume26en_US
dc.identifier.wosWOS:000188927400005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofBrain & Developmenten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectnitric oxideen_US
dc.subjectepileptic childrenen_US
dc.subjectvalproic aciden_US
dc.subjectcarbamazepineen_US
dc.titleSerum nitrite and nitrate levels in epileptic children using valproic acid or carbamazepineen_US
dc.typeArticleen_US

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