No association of Gaucher disease with COVID-19-related outcomes: a nationwide cohort study

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dc.authoridSonmez, Alper/0000-0002-9309-7715
dc.authoridSatman, Ilhan/0000-0001-8613-1797
dc.authoridsahin, mustafa/0000-0002-4718-0083
dc.authoridDemirci, Ibrahim/0000-0003-0498-3115
dc.authoridDagdelen, Selcuk/0000-0002-0513-1750
dc.authoridTASCI, ILKER/0000-0002-0936-2476
dc.authoridcelik, osman/0000-0003-2131-2866
dc.authorwosidCelik, Osman/KLZ-6766-2024
dc.authorwosidSonmez, Alper/H-8588-2019
dc.authorwosidSatman, Ilhan/AAS-7044-2020
dc.authorwosidsahin, mustafa/AAH-3394-2019
dc.authorwosidDemirci, Ibrahim/AAR-3277-2020
dc.authorwosidsalman, serpil/GRX-8413-2022
dc.authorwosidUnluturk, Ugur/A-1988-2016
dc.contributor.authorDemirci, Ibrahim
dc.contributor.authorDemir, Tevfik
dc.contributor.authorDagdelen, Selcuk
dc.contributor.authorHaymana, Cem
dc.contributor.authorTasci, Ilker
dc.contributor.authorAtmaca, Aysegul
dc.contributor.authorErtugrul, Derun
dc.date.accessioned2024-08-04T20:51:38Z
dc.date.available2024-08-04T20:51:38Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground It is well documented that patients with chronic metabolic diseases, such as diabetes and obesity, are adversely affected by the COVID-19 pandemic. However, when the subject is rare metabolic diseases, there are not enough data in the literature. Aim To investigate the course of COVID-19 among patients with Gaucher disease (GD), the most common lysosomal storage disease. Methods Based on the National Health System data, a retrospective cohort of patients with confirmed (polymerase chain reactionpositive) COVID-19 infection (n = 149 618) was investigated. The adverse outcomes between patients with GD (n = 39) and those without GD (n = 149 579) were compared with crude and propensity score-matched (PSM) groups. The outcomes were hospitalisation, the composite of intensive care unit (ICU) admission and/or mechanical ventilation and mortality. Results The patients with GD were significantly older and had a higher frequency of hypertension (HT), Type 2 diabetes mellitus (T2DM), dyslipidaemia, asthma or chronic obstructive pulmonary disease, chronic kidney disease, coronary artery disease, heart failure and cancer. Although hospitalisation rates in Gaucher patients were found to be higher in crude analyses, the PSM models (model 1, age and gender matched; model 2, matched for age, gender, HT, T2DM and cancer) revealed no difference for the outcomes between patients with GD and the general population. According to multivariate regression analyses, having a diagnosis of GD was not a significant predictor for hospitalisation (P = 0.241), ICU admission/mechanical ventilation (P = 0.403) or mortality (P = 0.231). Conclusion According to our national data, SARS-CoV-2 infection in patients with GD does not have a more severe course than the normal population.en_US
dc.identifier.doi10.1111/imj.15673
dc.identifier.endpage385en_US
dc.identifier.issn1444-0903
dc.identifier.issn1445-5994
dc.identifier.issue3en_US
dc.identifier.pmid34939733en_US
dc.identifier.scopus2-s2.0-85124148258en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage379en_US
dc.identifier.urihttps://doi.org/10.1111/imj.15673
dc.identifier.urihttps://hdl.handle.net/11616/100463
dc.identifier.volume52en_US
dc.identifier.wosWOS:000750641400001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofInternal Medicine Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGaucheren_US
dc.subjectcoronavirusen_US
dc.subjectCOVID-19en_US
dc.subjectSARS-CoV-2en_US
dc.subjectmortalityen_US
dc.subjectnationalen_US
dc.titleNo association of Gaucher disease with COVID-19-related outcomes: a nationwide cohort studyen_US
dc.typeArticleen_US

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