Biochemical and developmental effects of thyroid and anti-thyroid drugs on different early life stages of Xenopus laevis

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dc.authoridGungordu, Abbas/0000-0001-7770-0660
dc.authoridBoran, Filiz/0000-0002-8801-7987
dc.authorwosidGungordu, Abbas/A-3009-2015
dc.contributor.authorBoran, Filiz
dc.contributor.authorGungordu, Abbas
dc.date.accessioned2024-08-04T20:50:38Z
dc.date.available2024-08-04T20:50:38Z
dc.date.issued2021
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe effects of two drugs containing the synthetic thyroid hormone levothyroxine (LEV) and an anti-thyroid drug containing propylthiouracil (PTU) on the three early life stages of Xenopus laevis were evaluated with the Frog Embryo Teratogenesis Assay-Xenopus, Tadpole Toxicity Test, and Amphibian Metamorphosis Assay using biochemical and morphological markers. Tested drugs caused more effective growth retardation in stage 8 embryos than stage 46 tadpoles. Significant inhibition of biomarker enzymes has been identified in stage 46 tadpoles for both drugs. AMA test results showed that LEV-I caused progression in the developmental stage and an increase in thyroxine level in 7 days exposure and growth retardation in 21 days exposure in stage 51 tadpoles. On the other hand, increases in lactate dehydrogenase activity for both drugs in the AMA test may be due to impacted energy metabolism during sub-chronic exposure. These results also show that the sensitivity and responses of Xenopus laevis at different early developmental stages may be different when exposed to drugs.en_US
dc.identifier.doi10.1016/j.etap.2021.103738
dc.identifier.issn1382-6689
dc.identifier.issn1872-7077
dc.identifier.pmid34492396en_US
dc.identifier.scopus2-s2.0-85114412741en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.etap.2021.103738
dc.identifier.urihttps://hdl.handle.net/11616/100192
dc.identifier.volume87en_US
dc.identifier.wosWOS:000696705300011en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofEnvironmental Toxicology and Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLevothyroxineen_US
dc.subjectPropylthiouracilen_US
dc.subjectXenopus laevisen_US
dc.subjectEndocrine disruptor chemicalsen_US
dc.subjectBiomarkersen_US
dc.titleBiochemical and developmental effects of thyroid and anti-thyroid drugs on different early life stages of Xenopus laevisen_US
dc.typeArticleen_US

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