Association of eNOS Gene Polymorphisms G894T and T-786C with Risk of Hepatorenal Syndrome

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dc.authoridGozukara Bag, Harika Gozde/0000-0003-1208-4072
dc.authoridbilgic, yılmaz/0000-0002-2169-5548
dc.authoridTürköz, Yusuf/0000-0001-5401-0720
dc.authoridYesilada, Elif/0000-0002-3743-5767
dc.authoridYildirim, Oguzhan/0000-0001-8254-0104
dc.authoridCagin, Yasir Furkan/0000-0002-2538-857X
dc.authorwosidGozukara Bag, Harika Gozde/ABG-7588-2020
dc.authorwosidSeckin, Yuksel/ABI-3468-2020
dc.authorwosidbilgic, yılmaz/ABI-6432-2020
dc.authorwosidTürköz, Yusuf/ABG-7931-2020
dc.authorwosidaksungur, zeynep/AAW-2041-2021
dc.authorwosidYesilada, Elif/ABG-9600-2020
dc.authorwosidYildirim, Oguzhan/ABI-8174-2020
dc.contributor.authorSeckin, Yuksel
dc.contributor.authorYigit, Ali
dc.contributor.authorYesilada, Elif
dc.contributor.authorGulbay, Gonca
dc.contributor.authorCagin, Yasir Furkan
dc.contributor.authorGozukara, Harika
dc.contributor.authorBilgic, Yilmaz
dc.date.accessioned2024-08-04T20:42:37Z
dc.date.available2024-08-04T20:42:37Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractBackground. There are no studies investigating the relationship between endothelial nitric oxide synthase (eNOS) gene polymorphisms and hepatorenal syndrome (HRS). Aim. The purpose of this study is to elucidate whether eNOS gene polymorphisms (G894T and T-786C) play a role in the development of type-2 HRS. Methods. This study was carried out in a group of 92 patients with cirrhosis (44 patients with type-2 HRS and 48 without HRS) and 50 healthy controls. Polymorphisms were determined by polymerase chain reaction (PCR) and melting curve analysis. Results. We did not find any significant difference in allele and genotype distributions of the eNOS -T-786C polymorphism among the groups (p = 0.440). However, the frequency of GT (40.9%) and TT (13.6%) genotypes and mutant allele T (34.1%) for the eNOS G894T polymorphism were significantly higher (p < 0.001 and p < 0.001, resp.) in the HRS group than in both the stable cirrhosis (14.6%, 4.2%, and 11.5%, resp.) and the control (22.0%, 2.0%, and 13.0%, resp.) groups. Conclusion. The occurrence of mutant genotypes (GT/TT) and mutant allele T in eNOS -G894T polymorphisms should be considered as a potential risk factor in cirrhotic patients with HRS.en_US
dc.identifier.doi10.1155/2016/2579626
dc.identifier.issn1687-6121
dc.identifier.issn1687-630X
dc.identifier.pmid27594880en_US
dc.identifier.scopus2-s2.0-84983765444en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1155/2016/2579626
dc.identifier.urihttps://hdl.handle.net/11616/97486
dc.identifier.volume2016en_US
dc.identifier.wosWOS:000382036900001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherHindawi Ltden_US
dc.relation.ispartofGastroenterology Research and Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNitric-Oxide Synthaseen_US
dc.subjectCirrhotic-Patientsen_US
dc.subjectL-Arginineen_US
dc.subjectPlasmaen_US
dc.subjectInhibitionen_US
dc.subjectLiveren_US
dc.titleAssociation of eNOS Gene Polymorphisms G894T and T-786C with Risk of Hepatorenal Syndromeen_US
dc.typeArticleen_US

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