THE EFFECTS OF VINPOCETINE ON THE PREVENTION AND TREATMENT OF THE ISCHEMIA/REPERFUSION INJURY: AN EXPERIMENTAL STUDY

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dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridSahin, Levent/0000-0003-0193-4393
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authoridPolat, Alaadin/0000-0002-6920-3856
dc.authoridPolat, Alaadin/0000-0002-6920-3856
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidSahin, Levent/AAR-9222-2021
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidVardı, Nigar/C-9549-2018
dc.authorwosidPolat, Alaadin/Q-4052-2018
dc.authorwosidPolat, Alaadin/AAA-7171-2021
dc.contributor.authorSahin, Levent
dc.contributor.authorSarihan, M. Ediz
dc.contributor.authorParlakpinar, Hakan
dc.contributor.authorPolat, Alaadin
dc.contributor.authorVardi, Nigar
dc.date.accessioned2024-08-04T20:43:14Z
dc.date.available2024-08-04T20:43:14Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractObject: Histopathological and biochemical effects of vinpocetine, which is an anti-inflammatory and antioxidant agent, on ischemia / reperfusion (I/R) injury were studied in an animal model. Material and methods: Forty Sprague Dawley rats were divided into five groups. Group1 underwent only a right nephrectomy. Group 2 was administrated vinpocetine after right nephrectomy. Group 3 initially underwent a right nephrectomy. Them, left kidney of this group was applied ischemia for 60 minutes, which was followed by reperfusion for 24 hours. Group 4 underwent same steps as group 3; but was administrated vinpocetine 10 mg/kg i.p. before I/R to the left kidney. Similarly, group 5 underwent same steps as group 3 but was administrated vinpocetine 10 mg/kg i.p. after I/R to the left kidney. Results: Plasma BUN and creatinine showed no significant differences between control ( Sham) group and groups that were administrated vinpocetine. Decrease in plasma urea and creatinine was detected group 5, but this finding was not present in group 4. Superoxide dismutase and glutathione reductase levels in groups 4 and 5 were significantly higher than the group 3. Parallel to this, oxidative stress index was higher in the group 3compared to groups 2, 4, and 5 (p<0.05). No significant difference was found between levels of malondialdehite in sham and vinpocetine administrated only group (p<0.005). All groups showed no differences in catalase levels and Total Antioxidant Capacity. Decreased tubular injury was present in the groups administrated vinpocetine before and after I/R. In control and vinpocetine given groups, there were some apoptosis in tubules after tested with caspase 3. Caspase 3 positivity was significantly higher in I/R group compared to control group. Vinpocetine if given after I/R was more effective to prevent apoptosis then to be administrated before I/R. Conclusion: This experimental study showed that vinpocetine promotes achieving better renal functions. The results of this study suggest that vinpocetine may be used in the treatment of renal I/Ren_US
dc.identifier.doi10.19193/0393-6384_2017_5_127
dc.identifier.endpage862en_US
dc.identifier.issn0393-6384
dc.identifier.issn2283-9720
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85021734332en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage857en_US
dc.identifier.urihttps://doi.org/10.19193/0393-6384_2017_5_127
dc.identifier.urihttps://hdl.handle.net/11616/97876
dc.identifier.volume33en_US
dc.identifier.wosWOS:000405777000021en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherCarbone Editoreen_US
dc.relation.ispartofActa Medica Mediterraneaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnimal studyen_US
dc.subjectkidneyen_US
dc.subjectraten_US
dc.subjectreperfusion injuryen_US
dc.subjectvinpocetineen_US
dc.titleTHE EFFECTS OF VINPOCETINE ON THE PREVENTION AND TREATMENT OF THE ISCHEMIA/REPERFUSION INJURY: AN EXPERIMENTAL STUDYen_US
dc.typeArticleen_US

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