Histopathological and ophthalmoscopic evaluation of apocynin on experimental proliferative vitreoretinopathy in rabbit eyes

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dc.authoridParlakpinar, Hakan/0000-0001-9497-3468
dc.authoridÖzer, Murat atabey/0000-0003-1807-6911
dc.authoridPolat, Nihat/0000-0002-1735-1363
dc.authoridParlakpınar, Hakan/0000-0001-9497-3468
dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authorwosidoğurel, tevfik/K-3298-2019
dc.authorwosidParlakpinar, Hakan/V-6637-2019
dc.authorwosidÖzer, Murat atabey/ISV-0275-2023
dc.authorwosidPolat, Nihat/ABI-7316-2020
dc.authorwosidParlakpınar, Hakan/T-6517-2018
dc.authorwosidVardı, Nigar/C-9549-2018
dc.contributor.authorOzer, Murat Atabey
dc.contributor.authorPolat, Nihat
dc.contributor.authorOzen, Serkan
dc.contributor.authorOgurel, Tevfik
dc.contributor.authorParlakpinar, Hakan
dc.contributor.authorVardi, Nigar
dc.date.accessioned2024-08-04T20:42:36Z
dc.date.available2024-08-04T20:42:36Z
dc.date.issued2017
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of the current study was to evaluate the effect of apocynin (APO) on the development of proliferative vitreoretinopathy (PVR). New Zealand-type male rabbits were randomly grouped into three as follows: (1) Sham group rabbits which were applied intraperitoneal (i.p.) vehicle without PVR; (2) PVR group rabbits where PVR was created and an i.p. vehicle was administered for 21 successive days; (3) PVR + APO group rabbits where PVR was created and i.p. APO was administered for 21 successive days. Fundus examination was conducted with an indirect ophthalmoscope before starting the experiments and at each visit afterwards. At the end of the work, the rabbits were sacrificed under high-dose anesthesia and then eye tissues were taken for histopathological analyses. In the PVR + APO group, histopathologic and ophthalmoscopic examination revealed significant decrease in PVR formation. As the result, it has been observed that APO at least partially inhibits PVR formation.en_US
dc.identifier.doi10.1007/s10792-016-0318-0
dc.identifier.endpage605en_US
dc.identifier.issn0165-5701
dc.identifier.issn1573-2630
dc.identifier.issue3en_US
dc.identifier.pmid27495951en_US
dc.identifier.scopus2-s2.0-84982976361en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage599en_US
dc.identifier.urihttps://doi.org/10.1007/s10792-016-0318-0
dc.identifier.urihttps://hdl.handle.net/11616/97476
dc.identifier.volume37en_US
dc.identifier.wosWOS:000401918500022en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofInternational Ophthalmologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApocyninen_US
dc.subjectEyeen_US
dc.subjectRabbiten_US
dc.subjectProliferative vitreoretinopathyen_US
dc.titleHistopathological and ophthalmoscopic evaluation of apocynin on experimental proliferative vitreoretinopathy in rabbit eyesen_US
dc.typeArticleen_US

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