Metabolomic analysis of endometrial cancer by high-resolution magic angle spinning NMR spectroscopy

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dc.authoridDogan, Berat/0000-0003-4810-1970
dc.authoridSaridogan, Erdinc/0000-0003-2183-7689
dc.authoridKaraer, Abdullah/0000-0002-2010-6211
dc.authorwosidDogan, Berat/AAJ-7288-2020
dc.authorwosidSaridogan, Erdinc/ABE-3553-2020
dc.authorwosidKaraer, Abdullah/ABI-4667-2020
dc.contributor.authorDuz, Senem Arda
dc.contributor.authorMumcu, Akin
dc.contributor.authorDogan, Berat
dc.contributor.authorYilmaz, Ercan
dc.contributor.authorCoskun, Ebru Inci
dc.contributor.authorSaridogan, Erdinc
dc.contributor.authorTuncay, Gorkem
dc.date.accessioned2024-08-04T20:51:56Z
dc.date.available2024-08-04T20:51:56Z
dc.date.issued2022
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose To analyze endometrial metabolite profiles between patients with endometrial cancer and controls. Methods Seventeen (17) women with endometrium cancer and 18 controls were enrolled in this study. H-1 HR-MAS (High Resolution-Magic Angle Spinning) NMR (Nuclear Magnetic Resonance) spectroscopy data obtained from endometrial tissue samples of patients with endometrial cancer and control group were analyzed with bioinformatics methods. Results Principal component analysis (PCA) and the partial least squares discriminant analysis (PLS-DA) score plots obtained with the multivariate statistical analysis of pre-processed spectral data shows a separation between the samples from patients with endometrial cancer and controls. Analysis results suggest that the levels of lactate, glucose, o-phosphoethanolamine, choline, glycerophosphocholine, phosphocholine, leucine, isoleucine, valine, glutamate, glutamine, n-acetyltyrosine, methionine, taurine, alanine, aspartate and phenylalanine are increased in patients with endometrial cancer compared to the controls. Conclusion The metabolomics signature of patients with endometrial cancer is different from that of benign endometrial tissue.en_US
dc.description.sponsorshipScientific Research Projects Unit of Inonu University [TCD-2021-2359]; Scientific and Technological Research Council of Turkey (TUBITAK) [120C152]en_US
dc.description.sponsorshipThe study was supported by Scientific Research Projects Unit of Inonu University [under Grant number TCD-2021-2359]. B. D. is supported by The Scientific and Technological Research Council of Turkey (TUBITAK) under project number 120C152.en_US
dc.identifier.doi10.1007/s00404-022-06587-0
dc.identifier.endpage2166en_US
dc.identifier.issn0932-0067
dc.identifier.issn1432-0711
dc.identifier.issue6en_US
dc.identifier.pmid35567635en_US
dc.identifier.scopus2-s2.0-85130130007en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage2155en_US
dc.identifier.urihttps://doi.org/10.1007/s00404-022-06587-0
dc.identifier.urihttps://hdl.handle.net/11616/100650
dc.identifier.volume306en_US
dc.identifier.wosWOS:000795622500001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofArchives of Gynecology and Obstetricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEndometrial canceren_US
dc.subjectEndometrial tissueen_US
dc.subjectH-1-NMRen_US
dc.subjectMetabolomicsen_US
dc.titleMetabolomic analysis of endometrial cancer by high-resolution magic angle spinning NMR spectroscopyen_US
dc.typeArticleen_US

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