Ameliorating effects of quercetin and chrysin on 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced nephrotoxicity in rats

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dc.authoridVardı, Nigar/0000-0003-0576-1696
dc.authoridBeytur, Ali/0000-0002-7870-3318
dc.authoridCiftci, Osman/0000-0001-5755-3560
dc.authorwosidVardı, Nigar/C-9549-2018
dc.authorwosidBeytur, Ali/AAA-2823-2021
dc.authorwosidÖzdemir, İlknur/AAA-6216-2021
dc.contributor.authorCiftci, Osman
dc.contributor.authorOzdemir, Ilknur
dc.contributor.authorVardi, Nigar
dc.contributor.authorBeytur, Ali
dc.contributor.authorOguz, Fatih
dc.date.accessioned2024-08-04T20:36:11Z
dc.date.available2024-08-04T20:36:11Z
dc.date.issued2012
dc.departmentİnönü Üniversitesien_US
dc.description.abstractThe aim of this study is to investigate the beneficial effects of the quercetin (Q) and chrysin (CH) against nephrotoxicity induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a persistent environmental contaminant, in rats. Rats were divided randomly into six equal groups. TCDD, Q and CH were administered by gavages dissolved in corn oil at the doses of 2 mu g/kg/week, 20 mg/kg/day and 50 mg/kg/day, respectively. The kidney samples were taken from all rats on day 60 for the determination of thiobarbituric acid reactive substances (TBARS), glutathione (GSH), catalase (CAT), glutathione peroxidase (GPx) and superoxide dismutase (SOD) levels by spectrophotometric method. The results indicated that TCDD significantly induced lipid peroxidation and reduced antioxidant activities in rats. In contrast, Q and CH significantly prevented toxic effects of TCDD via increased GSH, CAT, GPx and SOD levels but decreased formation of TBARS. Also, it was determined that exposure to TCDD leads to significant histological damage in kidney tissue, and these effects can be eliminated with Q and CH treatment. In conclusion, the current study showed that exposure to TCDD can exert nephrotoxicity in rats. When Q and CH were given together with TCDD, they prevented nephrotoxic effects of TCDD. Their preventive effect lends more support to the role of oxidative and histological damage in the overall toxicity of TCDD.en_US
dc.description.sponsorshipIUBAP (Scientific Research Fund of University of Inonu) [2009/24.]en_US
dc.description.sponsorshipThe work was supported by IUBAP (Scientific Research Fund of University of Inonu) under Grant 2009/24.en_US
dc.identifier.doi10.1177/0748233711430978
dc.identifier.endpage954en_US
dc.identifier.issn0748-2337
dc.identifier.issn1477-0393
dc.identifier.issue10en_US
dc.identifier.pmid22173955en_US
dc.identifier.scopus2-s2.0-84868115069en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage947en_US
dc.identifier.urihttps://doi.org/10.1177/0748233711430978
dc.identifier.urihttps://hdl.handle.net/11616/95837
dc.identifier.volume28en_US
dc.identifier.wosWOS:000310161700011en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofToxicology and Industrial Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTCDDen_US
dc.subjectquercetinen_US
dc.subjectchrysinen_US
dc.subjectoxidative stressen_US
dc.subjectnephrotoxicityen_US
dc.titleAmeliorating effects of quercetin and chrysin on 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced nephrotoxicity in ratsen_US
dc.typeArticleen_US

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