Effect of bilirubin in ischemia reperfusion injury on rat small intestine

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dc.authorid113496en_US
dc.contributor.authorCeran Özcan, Canan
dc.contributor.authorSönmez, Kaan
dc.contributor.authorTürkyılmaz, Zafer
dc.contributor.authorDemiroğulları, Billur
dc.contributor.authorDursun, Ayşe
dc.contributor.authorDüzgün, Ersel
dc.contributor.authorBaşaklar, Abdullah Can
dc.contributor.authorKale, Nuri
dc.date.accessioned2017-08-16T07:57:28Z
dc.date.available2017-08-16T07:57:28Z
dc.date.issued2001
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose: The aim of this study was to determine the effects of bilirubin in experimental small intestinal ischemia/reperfusion (I/R) injury in rats. Methods: Thirty rats were divided into 5 groups (n 5 6). In group S, saline and in group B, bilirubin, 20 mg/kg were infused via the jugular vein without an additional procedure. In groups S-IR, saline, B1-IR and B2-IR, 10 and 20 mg/kg/h of bilirubin were infused for 2 hours, respectively. In these groups, an I/R procedure was done after infusions by occluding the superior mesenteric artery for 45 minutes followed by 1 hour of reperfusion. After reperfusion, the small intestines were resected for histopathologic and malondialdehyde (MDA) assessments. Mucosal lesions were scored between 0 and 5. Malondialdehyde levels and histopathologic grades were analyzed statistically. Results: Mucosal injury was severe in S-IR (grade 4 to 5), mild in B1-IR (grade 0 to 3) and none in B2-IR group (grade 0). Grades of group S-IR were higher than those of B1-IR and B2-IR statistically (P ,.05). Tissue MDA levels of the S-IR group were significantly higher than those of B1-IR and B2-IR groups (U 5 36, P , .05). Bilirubin levels correlated inversely with MDA levels (r 5 20.94). Conclusions: Bilirubin effectively prevents intestinal I/R injury in rat. This observation is consistent with the hypotheses regarding bilirubin as an antioxidant, having a role in the body defense.en_US
dc.identifier.citationCeran Özcan, C. Sönmez, K. Türkyılmaz, Z. Demiroğulları, B. Dursun, A. Düzgün, E. Başaklar, A. C. Kale, N. (2001). Effect of bilirubin in ischemia reperfusion injury on rat small intestine. Journal of Pediatric Surgery, 36(12), 1764–1767.en_US
dc.identifier.doi10.1053/jpsu.2001.28816en_US
dc.identifier.endpage1767en_US
dc.identifier.issn00223468
dc.identifier.issue12en_US
dc.identifier.startpage1764en_US
dc.identifier.urihttp://linkinghub.elsevier.com/retrieve/pii/S0022346801910218
dc.identifier.urihttps://hdl.handle.net/11616/7584
dc.identifier.volume36en_US
dc.language.isoenen_US
dc.publisherJournal of Pediatric Surgeryen_US
dc.relation.ispartofJournal of Pediatric Surgeryen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBilirubinen_US
dc.subjectIschemia/reperfusion injuryen_US
dc.subjectIntestineen_US
dc.titleEffect of bilirubin in ischemia reperfusion injury on rat small intestineen_US
dc.typeArticleen_US

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