Caffeic acid phenethyl ester ameliorated ototoxicity induced by cisplatin inrats

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dc.authorid7028en_US
dc.contributor.authorKızılay, Ahmet
dc.contributor.authorKalcıoğlu, Mahmut Tayyar
dc.contributor.authorÖzerol, Elif
dc.contributor.authorIraz, Mustafa
dc.contributor.authorGüleç, Mukaddes
dc.contributor.authorAkyol, Ömer
dc.contributor.authorÖzturan, Orhan
dc.date.accessioned2017-06-03T10:42:40Z
dc.date.available2017-06-03T10:42:40Z
dc.date.issued2004
dc.departmentİnönü Üniversitesien_US
dc.description.abstractCaffeic acid phenethyl ester (CAPE), an active component of propolis, exhibits antioxidant properties. This experimental study was designed to determine the effect of CAPE on ototoxicity induced with cisplatin. Twenty-four adult Wistar albino rats were divided into four groups: cisplatin (n=6), saline (n=6), CAPE (n=6), and cisplatin plus CAPE (n=6). Rats were tested before and 5 days after cisplatin treatment with or without chemo protection. The Distortion Product Otoacoustic Emissions (DPOAEs) were elicited from the control and experimental animals utilizing the standard commercial Otoacoustic Emission (OAEs) apparatus. The animals in all groups were sacrificed under general anesthesia on the fifth day following last OAE measurements. For biochemical investigations, the blood samples were drawn from inferior vena cava On day 0, the initial baseline DPOAEs measurement results presented similar values while comparing the groups in drug free phase (p>0.05). On day 5, intrasubject measurement parameters of DPgrams and I/O functions of cisplatin group were significantly deteriorated (p<0.05). The second measurements of the other groups revealed no significant differences between their DPgrams and I/O functions in all frequencies (p>0.05). Among the biochemical parameters, plasma xanthine oxidase (XO) activity was found to be more elevated in the cisplatin group than the saline group (p<0.05). CAPE led to more decreased XO activity than cisplatin (p<0.05). The results of this study show that prophylactic administration of CAPE for cisplatin ototoxicity ameliorated hearing deterioration in rats.en_US
dc.identifier.citationKızılay, A. Kalcıoğlu, M. T. Özerol, E. Iraz, M. Güleç, M. Akyol, Ö. Özturan, O. (2004). Caffeic acid phenethyl ester ameliorated ototoxicity induced by cisplatin inrats . J Chemother., 16(4), 381–387.en_US
dc.identifier.endpage387en_US
dc.identifier.issue4en_US
dc.identifier.startpage381en_US
dc.identifier.urihttps://hdl.handle.net/11616/7032
dc.identifier.volume16en_US
dc.language.isoenen_US
dc.publisherJ Chemotheren_US
dc.relation.ispartofJ Chemotheren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOtotoxicityen_US
dc.subjectCisplatinen_US
dc.subjectAntioxidant agentsen_US
dc.subjectCaffeic acid phenethyl esteren_US
dc.subjectOtoacoustic emissionsen_US
dc.subjectOuter hair cellsen_US
dc.subjectRaten_US
dc.titleCaffeic acid phenethyl ester ameliorated ototoxicity induced by cisplatin inratsen_US
dc.typeArticleen_US

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