Adropin: a key component and potential gatekeeper of metabolic disturbances in policystic ovarian syndrome

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dc.authoridAydın, Serdar/0000-0002-2043-395X
dc.authorwosidAydın, Serdar/AAR-9362-2020
dc.contributor.authorYildirim, B.
dc.contributor.authorCelik, O.
dc.contributor.authorAydin, S.
dc.date.accessioned2024-08-04T20:39:44Z
dc.date.available2024-08-04T20:39:44Z
dc.date.issued2014
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose: The aim of the current study was to evaluate potential relationships between serum adropin levels and metabolic parameters in polycystic ovary syndrome (PCOS). Materials and Methods: Twenty women with PCOS and 20 healthy, age and body mass index (BMI) matched controls were included in the study. All subjects underwent venous blood drawing on the early follicular phase after an overnight fasting. Serum adropin levels were measured with enzyme immunosorbent assay (ETA). The relationships between serum adropin levels and metabolic parameters were also assessed. Results: Serum adropin levels were found to be significantly lower in women with PCOS when compared to control group (p < 0.001). Serum adropin level was correlated negatively with fasting serum insulin levels, homeostasis model of assessment - insulin resistance (HOMA-IR) and serum lipid markers including cholesterol, very low-density lipoprotein, and triglycerides (TG) in PCOS patients (p < 0.05). Conclusion: The findings of current study suggest that women with PCOS have low serum adropin levels that may contribute to the underlying pathogenesis of metabolic disturbances in PCOS.en_US
dc.identifier.endpage312en_US
dc.identifier.issn0390-6663
dc.identifier.issue3en_US
dc.identifier.pmid24992783en_US
dc.identifier.scopus2-s2.0-84902455521en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage310en_US
dc.identifier.urihttps://hdl.handle.net/11616/96477
dc.identifier.volume41en_US
dc.identifier.wosWOS:000343848800015en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisher7847050 Canada Incen_US
dc.relation.ispartofClinical and Experimental Obstetrics & Gynecologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdropinen_US
dc.subjectPCOSen_US
dc.subjectInsulin resistanceen_US
dc.subjectHOMA-IRen_US
dc.titleAdropin: a key component and potential gatekeeper of metabolic disturbances in policystic ovarian syndromeen_US
dc.typeArticleen_US

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