The effects of iron deficiency on red blood cell transfusion requirements in non-bleeding critically ill patients

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dc.authoridYücel, Aytaç/0000-0003-0270-8339
dc.authoridUçar, Muharrem/0000-0002-1232-9829
dc.authoridaydogan, mustafa said/0000-0002-7106-1156
dc.authorwosidYücel, Aytaç/ABI-6137-2020
dc.authorwosidUçar, Muharrem/ABH-7761-2020
dc.authorwosidaydogan, mustafa said/AAA-2828-2021
dc.contributor.authorAydogan, Mustafa Said
dc.contributor.authorUcar, Muharrem
dc.contributor.authorYucel, Aytac
dc.contributor.authorKarakas, Bugra
dc.contributor.authorGok, Abdullah
dc.contributor.authorTogal, Turkan
dc.date.accessioned2024-08-04T20:42:32Z
dc.date.available2024-08-04T20:42:32Z
dc.date.issued2016
dc.departmentİnönü Üniversitesien_US
dc.description.abstractIntroduction: Critically ill patients often need blood transfusion, but no reliable predictors of transfusion requirements are available at Intensive Care Unit (ICU) admission. We hypothesized that ICU patients admitted with Iron Deficiency (ID) may be at higher risk for developing anemia, requiring blood transfusion. The aims of this study were to determine the frequency of ID in ICU patients admission and to investigate its relationship with transfusion requirements in ICU patients. Methods: Two hundred ninety-six patients admitted to the general ICU were enrolled in the prospective observational study. We studied 268 patients, after excluding those transfused on or before ICU admission. The patients recorded age, gender, diagnosis, severity scores, presence of sepsis, ICU complications, ICU treatments, and transfusion-free interval. ID was assessed on the basis of several parameters, including hemoglobin, hematocrit, levels of serum iron, transferrin saturation, levels of ferritin, soluble transferrin receptor, C-reactive protein. Results: The mean age was 48 years. Of 268 patients (138 male/130 female), 114 (42.8%) had ID with outcomes of blood samples were used at ICU admission. The overall transfusion rate was 38.8%, being higher in ID patients than in normal iron profile patients (40.3 vs. 18.9%, P= 0.001). After adjusting for severity of illness and hemoglobin level, ID patients remained significantly associated with transfusion, with a hazard ratio of 5.3 (95% CI, 1.8-14.8; P= 0.001). Conclusion: ID is common at ICU admission and is associated with higher transfusion requirements. These findings have important implications for transfusion practices for in ICU patients.en_US
dc.identifier.endpage847en_US
dc.identifier.issn0970-938X
dc.identifier.issn0976-1683
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-84978961896en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage844en_US
dc.identifier.urihttps://hdl.handle.net/11616/97427
dc.identifier.volume27en_US
dc.identifier.wosWOS:000388456100045en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherAllied Acaden_US
dc.relation.ispartofBiomedical Research-Indiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIron deficiencyen_US
dc.subjectAnaemiaen_US
dc.subjectBlood transfusionen_US
dc.subjectCritical illnessen_US
dc.titleThe effects of iron deficiency on red blood cell transfusion requirements in non-bleeding critically ill patientsen_US
dc.typeArticleen_US

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