Does Calcium Dobesilate Have Therapeutic Effect on Gentamicin-induced Cochlear Nerve Ototoxicity? An Experimental Study

Basit Öğe Kaydı
dc.authoridGül, Mehmet/0000-0002-1374-0783
dc.authoridEdizer, Deniz Tuna/0000-0003-4448-1881
dc.authoridatas, ahmet/0000-0002-8673-6793
dc.authorwosidAtas, Ahmet/D-4190-2019
dc.authorwosidGül, Mehmet/ABI-6336-2020
dc.authorwosidEdizer, Deniz Tuna/GWQ-5748-2022
dc.authorwosidatas, ahmet/AAS-9417-2020
dc.contributor.authorCinar, Zehra
dc.contributor.authorEdizer, Deniz Tuna
dc.contributor.authorYigit, Ozgur
dc.contributor.authorAltunay, Zeynep Onerci
dc.contributor.authorGul, Mehmet
dc.contributor.authorAtas, Ahmet
dc.date.accessioned2024-08-04T20:49:04Z
dc.date.available2024-08-04T20:49:04Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractHypothesis: The ototoxic effects of aminoglycosides are well known. Gentamicin carries a substantial risk of hearing loss. Gentamicin is widely used to combat life-threatening infections, despite its ototoxic effects. Calcium dobesilate is a pharmacologically active agent used to treat many disorders due to its vasoprotective and antioxidant effects. We investigated the therapeutic role of calcium dobesilate against gentamicin-induced cochlear nerve ototoxicity in an animal model. Methods: Thirty-two Sprague Dawley rats were divided into four groups: Gentamicin, Gentamicin + Calcium Dobesilate, Calcium Dobesilate, and Control. Preoperative and postoperative hearing thresholds were determined using auditory brainstem response thresholds with click and 16-kHz tone-burst stimuli. Histological analysis of the tympanic bulla specimens was performed under light and transmission electron microscopy. The histological findings were subjected to semiquantitative grading, of which the results were compared between the groups. Results: Gentamicin + Calcium Dobesilate group had, on average, 27 dB better click-evoked hearing than Gentamicin group (p < 0.01), whereas the difference was not significant with 16-kHz tone-burst stimuli (p > 0.01). Histologically examining the Control and Calcium Dobesilate groups revealed normal ultrastructural appearances. The Gentamicin group showed the most severe histological alterations including myelin destruction, total axonal degeneration, and edema. The histological evidence of damage was significantly reduced in the Gentamicin + Calcium Dobesilate group compared with the Gentamicin group. Conclusion: Adding oral calcium dobesilate to systemic gentamicin was demonstrated to exert beneficial effects on click-evoked hearing thresholds, as supported by the histological findings.en_US
dc.identifier.doi10.1097/MAO.0000000000002820
dc.identifier.endpageE1192en_US
dc.identifier.issn1531-7129
dc.identifier.issn1537-4505
dc.identifier.issue10en_US
dc.identifier.pmid32976341en_US
dc.identifier.scopus2-s2.0-85096080178en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpageE1185en_US
dc.identifier.urihttps://doi.org/10.1097/MAO.0000000000002820
dc.identifier.urihttps://hdl.handle.net/11616/99628
dc.identifier.volume41en_US
dc.identifier.wosWOS:000588527500002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofOtology & Neurotologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCalcium Dobesilateen_US
dc.subjectCochlear nerveen_US
dc.subjectGentamicinen_US
dc.subjectHearing lossen_US
dc.subjectOtotoxicityen_US
dc.titleDoes Calcium Dobesilate Have Therapeutic Effect on Gentamicin-induced Cochlear Nerve Ototoxicity? An Experimental Studyen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu