Squamous cell carcinomas of the soft palate treated with radiation therapy alone or followed by planned neck dissection

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dc.authorwosidErkal, Haldun Sukru/AAC-8209-2019
dc.contributor.authorErkal, HS
dc.contributor.authorSerin, M
dc.contributor.authorAmdur, RJ
dc.contributor.authorVillaret, DB
dc.contributor.authorStringer, SP
dc.contributor.authorMendenhall, WM
dc.date.accessioned2024-08-04T20:12:17Z
dc.date.available2024-08-04T20:12:17Z
dc.date.issued2001
dc.departmentİnönü Üniversitesien_US
dc.description.abstractPurpose: The present study presents the experience at the University of Florida with treatment of unselected patients with carcinomas of the soft palate with radiation therapy (RT) alone or followed by planned neck dissection. Methods and Materials: One hundred seven patients treated with curative intent with RT alone or followed by neck dissection from 1965 to 1996 were included in the study. All patients had follow-up for at least 2 years. No patients were lost to follow-up. Results: Local control rates at 5 years were 86% for T1, 91% for T2, 67% for T3, and 36% for T4 carcinomas. T-stage and overall treatment time significantly affected local control in multivariate analysis. Nodal control rates at 5 years were 86% for NO, 76% for N1, 61% for N2, and 67% for N3 carcinomas. Overall treatment time and planned neck dissection significantly affected nodal control in multivariate analysis. Ultimate local-regional control rates at 5 years were 90% for Stage I, 92% for Stage II, 84% for Stage III, and 60% for Stage IV disease. Overall treatment time and planned neck dissection significantly affected ultimate local-regional control in multivariate analysis. The overall survival rate at 5 years was 42% for all patients. Overall stage; overall treatment time, and planned neck dissection significantly affected overall survival in multivariate analysis. The cause-specific survival rate at 5 years was 70% for all patients. Overall treatment time and planned neck dissection significantly affected cause-specific survival in multivariate analysis. Three patients sustained severe postoperative complications and 3 patients sustained severe late complications. Sixteen patients had synchronous and 14 patients had metachronous carcinomas of the head and neck mucosal sites. Conclusion: For limited carcinomas of the soft palate, RT (alone or followed by planned neck dissection) results in relatively high local-regional control and survival rates. For advanced carcinomas of the soft palate, local-regional control and survival rates are relatively low and local-regional recurrence rates are substantial. Advanced carcinomas of the soft palate may be better treated with RT and concomitant chemotherapy. (C) 2001 Elsevier Science Inc.en_US
dc.identifier.doi10.1016/S0360-3016(00)01578-9
dc.identifier.endpage366en_US
dc.identifier.issn0360-3016
dc.identifier.issue2en_US
dc.identifier.pmid11380222en_US
dc.identifier.scopus2-s2.0-0035371162en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage359en_US
dc.identifier.urihttps://doi.org/10.1016/S0360-3016(00)01578-9
dc.identifier.urihttps://hdl.handle.net/11616/93334
dc.identifier.volume50en_US
dc.identifier.wosWOS:000168781000010en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofInternational Journal of Radiation Oncology Biology Physicsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectsoft palateen_US
dc.subjectsquamous cell carcinomaen_US
dc.subjectradiotherapyen_US
dc.subjectplanned neck dissectionen_US
dc.titleSquamous cell carcinomas of the soft palate treated with radiation therapy alone or followed by planned neck dissectionen_US
dc.typeArticleen_US

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