Update on Hepatocellular Carcinoma: a Brief Review from Pathologist Standpoint

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dc.authoridKaradag Soylu, Nese/0000-0002-6303-5484
dc.authorwosidKaradag Soylu, Nese/ABH-9544-2020
dc.contributor.authorSoylu, Nese Karadag
dc.date.accessioned2024-08-04T20:48:50Z
dc.date.available2024-08-04T20:48:50Z
dc.date.issued2020
dc.departmentİnönü Üniversitesien_US
dc.description.abstractHepatocellular carcinoma is one of the most common cancers and an important health problem all over the world. Its prognosis is poor. For better patient care, early diagnosis is essential. Although new imaging techniques have a big impact on hepatocellular carcinoma diagnosis, histopathological examination is still the gold standard for precise diagnosis. Histopathological evaluation gives exact diagnosis in the meaning of tumor size, histological subtypes, grading, and differential diagnosis from metastasis and other tumors. Immunohistochemistry as a part of diagnostic histopathological technique plays an important role in routine practice. Immunohistochemistry is useful for confirming of hepatocytic origin, supporting hepatocellular malignancy, and differential diagnosis. It also gives prognostic information. There are growing attempts to classify tumors by their molecular genetic signatures. This is also actual for hepatocellular carcinoma. This mini review focuses on the histopathology of hepatocellular carcinoma including subtypes; differential diagnosis and immunohistochemistry as an ancillary diagnostic tool, updated or added entities, i.e., combined hepatocellular-cholangiocarcinoma; small hepatocellular carcinoma; correlation with molecular studies; and future perspectives.en_US
dc.identifier.doi10.1007/s12029-020-00499-5
dc.identifier.endpage1186en_US
dc.identifier.issn1941-6628
dc.identifier.issn1941-6636
dc.identifier.issue4en_US
dc.identifier.pmid32844348en_US
dc.identifier.scopus2-s2.0-85089856183en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1176en_US
dc.identifier.urihttps://doi.org/10.1007/s12029-020-00499-5
dc.identifier.urihttps://hdl.handle.net/11616/99486
dc.identifier.volume51en_US
dc.identifier.wosWOS:000562746100002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Gastrointestinal Canceren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHepatocellular carcinomaen_US
dc.subjectHistopathologyen_US
dc.subjectImmunohistochemistryen_US
dc.subjectBiopsyen_US
dc.titleUpdate on Hepatocellular Carcinoma: a Brief Review from Pathologist Standpointen_US
dc.typeReview Articleen_US

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